QTc prolongationBenefits of serial electrocardiographic (ECG) monitoring to detect QT prolongation in patients with hematological malignancies remain unclear. This retrospective, single-center, study evaluated 316 adult acute leukemia and high-risk MDS patients who received 11,775 patient-days of ...
1.治疗前QTc间期延长>450ms(男)、>470ms(女),而≤500ms:(1)30min内复查 ECG,手动计算QTc值;(2)判断是否有如下体征/症状,如心悸、心动过速、头晕、晕厥、胸痛、意识丧失;(2)根据电解质水平补充电解质,其中血钾水平应该是最优先需要保证的;如果出现难治性低血钾,考虑钾和镁的替代治疗;(3)禁止使用贝达喹啉...
We report the case of a female patient with congenital complete atrioventricular block who developed torsade de pointes (TdP) in the course of takotsubo cardiomyopathy. On the basis of this case, we show that the electrocardiographic evolutionary changes with QT interval prolongation (in the course ...
ECG相关参数,包括(形态、心率、节律、P波电压、R波电压、T波电压、PR间期、RR间期、QRS时间、QT间期、QTc间期) 猴 Ishizaka T et al Evaluation of drug-induced QT prolongation in a halothane-anesthetized monkey model: effects of sotalolJ PharmacolToxicol Methods,2009;59:86-93 猪 Authier S et al Ca...
药物引起QT间期显著延长将使致命性心律失常TdP发生的风险显著增加,因而ECG的QT间期被作为预测新化合物引起TdP的重要风险因素。鉴于犬、猴和小型猪等大动物在心肌离子通道构成和功能方面与人类具有高度相似性,通常用于整体QT分析研究中。整体QT分析试验...
(3)慎重将红霉素、克拉霉素、莫西沙星等与复方甘草合用,如联合应用注意 ECG 和 QT/QTc 变化,适量补充钾剂;当三环类抗抑郁药与可延长 QT/QTc 的其他药物如抗组胺药物、抗精神病药物及胃肠动力药物合用时尤其需要注意。 对于肿瘤患者重点强调随访与预防并重原则[6]: ...
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Prolonged QT interval on the electrocardiogram (ECG) is associated with an increased risk of cardiac arrhythmia and sudden death. Many drugs used in palliative medicine increase the QT interval and several have had their licenses withdrawn or severely restricted. The relative importance of prolonged QT...
药物引起QT间期显著延长将使致命性心律失常TdP发生的风险显著增加,因而ECG的QT间期被作为预测新化合物引起TdP的重要风险因素。鉴于犬、猴和小型猪等大动物在心肌离子通道构成和功能方面与人类具有高度相似性,通常用于整体QT分析研究中。整体QT分析试验可在麻醉和清醒动物进行,具体方法参见表3所列文献。
All patients underwent continuous cardiac telemetry monitoring and/or had a baseline 12-lead ECG obtained within 4 hours of admission. QT intervals were determined manually from lead II of 12-lead ECGs or from continuous lead II telemetry monitoring strips. QT(c) interval prolongation was defined ...