Prolongation of the QT interval represents delayed ventricular repo-larization. At the cellular level, the outward movement of potassium ions drives repolarization. Medications that block these potassium channels impede myocardial repolarization and prolong the QT interval, which may result in potentially ...
[2] Lasser KE, Allen PD,Woolhandler SJ, et al. Timing of new black box warnings and withdrawals for preion medications. JAMA 2002;287:2215 - 20. [3] Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350(10):1013-1022. [4] Drew BJ, Ackerman MJ, Funk ...
[2]Lasser KE, Allen PD,Woolhandler SJ, et al. Timing of new black box warnings and withdrawals for prescription medications. JAMA 2002;287:2215 - 20. [3]Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350(10):1013-1022. [4]Drew BJ, Ackerman MJ, Funk ...
参考文献: [1]Juan Carlos Ruiz Diaz, Daniel Frenkel & Wilbert S. Aronow. The relationship b etween atypical antipsychotics drugs, QT interval prolongation, and torsades de pointes: implications for clinical use, Expert Opinion on Drug Safety[J],2020(19) 1, 559-564, DOI: 10.1080/14740338.2020....
[2] Lasser KE, Allen PD,Woolhandler SJ, et al. Timing of new black box warnings and withdrawals for preion medications. JAMA 2002;287:2215 - 20. [3] Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350(10):1013-1022. ...
5. Isbister GK, Brown AL, Gill A, Scott AJ, et al. QT interval prolongation in opioid agonist treatment: analysis of continuous 12-lead electrocardiogram recordings. Br J Clin Pharmacol. 2017 Oct; 83(10): 2274-2282.
QT interval. If QT prolongation occurs, removal or substitution of current agents should be considered. Pharmacists must also take note of the clearance of QT-prolonging medications. Decreased hepatic and renal function may increase the patient’s exposure to QT-prolonging medications, thereby ...
[2] Lasser KE, Allen PD,Woolhandler SJ, et al. Timing of new black box warnings and withdrawals for prescription medications. JAMA 2002;287:2215 - 20. [3] Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350(10):1013-1022. ...
ContextOf the several factors implicated in causing QT interval prolongation and torsades de pointes, errors in the use of medications that may
Overestimate QTc interval in tachycardia Underestimate the QTc interval in bradycardia This overcall can lead to unnecessary withholding of first-line medications. Thus manual measurement using the Fredericia or Framingham corrections, or population-based nomograms have the best rate correction. These ...