There was no correlation between the dose of methadone (range 55 mg to 145 mg) and the QTc interval (p > .05).The QT interval in pregnant women on methadone was below the upper limit of normal, except for those with a cocaine-positive utox. The concomitant used cocaine place pregnant ...
Objectives: To evaluate the degree of QT dispersion in a group of young women in the starvation phase of anorexia nervosa (AN) and its relation to left ventricular (LV) mass. Study design: Sixteen patients with self-induced starvation were matched with 16 women of normal weight and 16 consti...
The normal QT interval is controversial, and multiple normal durations have been reported. In general, the normal QT interval is below 400 to 440 milliseconds (ms), or 0.4 to 0.44 seconds. Women have a longer QT interval than men. Lower heart rates also result in a longer QT interval. A...
We attempted to evaluate whether subjects who exhibit prolonged corrected QT (QTc) interval (≥440 ms in men and ≥460 ms in women) on ECG, with and without ECG-diagnosed left ventricular hypertrophy (ECG-LVH; Cornell product, ≥244 mV×ms), are at increased risk of stroke. Among the 10...
ContextOf the several factors implicated in causing QT interval prolongation and torsades de pointes, errors in the use of medications that may
In both cases, deviation from normal ion channel function leads to transmural dispersion of repolarization currents across the myocardium, triggering early after depolarizations which may devolve into TdP (1). Prolonged QT interval alone does not denote imminent risk for TdP; TdP is often self-limit...
The aim of the study was to investigate whether cardiac amyloidosis is associated with QT interval abnormalities and ventricular arrhythmias. A controlled study of 30 patients was undertaken at a university cardiology department in a large referral hospital. Thirty patients (18 men, 12 women, mean ...
Endogenous testosterone and progesterone shorten the action potential, and estrogen lengthens the QT interval. During a single menstrual cycle, progesterone levels, but not estrogen levels, have the dominant effect on ventricular repolarization in women. Studies of menopausal hormone therapy (MHT) in ...
On day 0, the QTc intervals within the normal range were observed both in women and men. The first peak of the QTc interval was observed on day 2 with the mean QTc interval of 475 ± 70 ms in women, and 474 ± 60 ms in men. Once the QTc interval shortened after the first peak,...
For sudden cardiac death, the respective ratios were 1.63 (1.32–2.25) per 1-SD increase in QTc; and 3.32 (2.14–4.23). QTc interval did not change during the first year after surgery, but increased significantly during the subsequent years. Patients with prolonged QTc before surgery had ...