A number of other chemically different HDACI are currently in clinical trials for the treatment of breast cancer, lymphoma, neurological diseases or immune disorders [25,26]. The HDACI mimic the structure of the natural HDAC substrate acetyl lysine. Their pharmacophoric model consists of: (i) ...
The Thr-in conformation facilitated the separate protonation and nucleophilic attack mechanism with the lowest ∆G‡ value of 116.7 kJ/mol, which is still nearly 40% above the experimental value [133]. A recent study of tens of thousands of organic compounds for pharmacophoric screening was ...