A novel GDP-dependent pyruvate kinase isozyme from Toxoplasma gondii localizes to both the apicoplast and the mitochondrion. Saito, Tomoya,Nishi, Manami,Lim, Muoy I.,Wu, Bo,Maeda, Takuya,Hashimoto, Hisayuki,Takeuchi, Tsutomu,Roos, David S.,Asai, Takashi. Journal of Biological Chemistry . 2008...
Cytosolic pyruvate originates from several sources (Fig.1). In most cells, the major source of pyruvate is the last step of glycolysis, where pyruvate kinase converts phosphoenolpyruvate to pyruvate. Other significant sources include lactate via lactate dehydrogenase (LDH) and alanine via alanine ami...
To gain insight into the functional and metabolic consequences of glucose oxidation in ECs, we analysed the function of the pyruvate kinase (PK) isozyme PKM2, which has been associated with aerobic glycolysis and growth in cancer cells10,11, and the maintenance of mitochondrial function in diabetic...
Alias PKM2(Pyruvate kinase isozymes M1, M2), CTHBP, OIP3, p58, PK2, PK3, TCB, THBP1, Tumor M2-PK, Cytosolic thyroid hormone-binding protein, OIP-3, Opa-interacting protein 3, PK, muscle type, Pyruvate kinase 2, 3, Pyruvate kinase muscle isozyme, TCB, Thyroid hormone-binding protein ...
The allosteric regulation of PK is directly related to proliferation of certain cell types, as demonstrated by the expression of an allosterically regulated isozyme in tumor cells. A model for the allosteric transition from the inactive (T) state to the active (R) state has been proposed ...
Pyruvate kinase muscle isozyme M2 (PKM2) is a rate-limiting glycolytic enzyme that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to ADP, thus generating ATP and pyruvate (9). A recent study suggests PKM2 as a link between metabolic and inflammatory dysfunction in ...
英文名称:Anti-M2-PK (pyruvate Kinase M2) 别名: CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; OPA interacting protein 3; Opa interactivity protein; PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PKM2; PYKM; Pyruvate kinase ...
CLONING AND CHARACTERIZATION OF A CDNA FOR THE CYTOSOLIC ISOZYME OF PLANT PYRUVATE-KINASE - THE RELATIONSHIP BETWEEN THE PLANT AND NON-PLANT ENZYME The effects of seasonal change, November versus July, and prolonged anoxia (96h under N 2 gas) on the properties of phosphofructokinase and pyruvate ...
These cytosolic enzymes are dimers with subunit molecular weights of 25,000-28,OOO which, on the basis of isoelectric point, substrate specificity and primary sequence similarity, can be divided into at least three classes: a, p and x (refs. 16,17). Crystal structures have now been ...
mammalian target of rapamycin, in multiprotein complex 1; mTORc2: mammalian target of rapamycin, in multiprotein complex 2; PDK1: pyruvate dehydrogenase lipoamide kinase isozyme 1; PI3K: phosphatidylinositol 3-kinase; PIP2: phosphatidylinositol (3,4,5)-biphosphate; PIP3: phosphatidylinositol (3,...