hypoxia-inducible factor 1αmitochondriapyruvate dehydrogenase kinasetumor metabolismCurrent drug development in oncology is non-selective as it typically focuses on pathways essential for the survival of all dividing cells. The unique metabolic profile of cancer, which is characterized by increased ...
Pyruvate dehydrogenase kinase isoform 4 (PDK4) is upregulated by starvation in many tissues of the body during starvation. This causes inactivation of the ... Pengfei Wu a,Jeffrey M. Peters b,Robert A. Harris a - 《Biochemical & Biophysical Research Communications》 被引量: 936发表: 2001年...
英文名称:Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 别名:mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; HGNC:8809; Mitochondrial pyruvate dehydrogenase kinase isoenzyme 1; PDK1; PDK 1; PDK-1; Pyruvate dehydrogenase kinase isoform 1; Pyruvate dehydrogenase kinase, isoenzyme ...
Pyruvate dehydrogenase kinase(PDK) is upregulated in a variety of cancers, which, in turn, inactivatesPDHand induces a glycolytic phenotype.Hypoxia, via the activation of hypoxia-inducible factor 1α (HIF-1α), induces the expression of the PDKisoformPDK3[44]. Interestingly, under both normoxic...
抗体名:PDHK1; mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; HGNC:8809; Mitochondrial pyruvate dehydrogenase kinase isoenzyme 1; PDK 1; PDK-1; Pyruvate dehydrogenase kinase isoform 1; Pyruvate dehydrogenase kinase, isoenzyme 1; PDK1_HUMAN.靶点:详见说明书 ...
该PDK1, Recombinant, Human, GST-Tag ([Pyruvate Dehydrogenase [Lipoamide]] Kinase Isozyme 1, Mitochondrial, Pyruvate Dehydrogenase Kinase Isoform 1)产品的产品序列,详细查看产品说明书。 来源宿主 提供的PDK1, Recombinant, Human, GST-Tag ([Pyruvate Dehydrogenase [Lipoamide]] Kinase Isozyme 1, Mitochondria...
Libraries of non-purified resorcinol amide derivatives were screened by surface plasmon resonance (SPR) to determine the binding dissociation constant (off-rate, KD) for compounds binding to the pyruvate dehydrogenase kinase (PDHK) enzyme. Parallel off-rate measurements against HSP90 and application of...
The use of pyruvate dehydrogenase kinase inhibitors can be one of the strategies in order to prevent multi-organ failure due to cytokine storm. It has been reported through in-vivo studies that mice when infected with H1N1 virus at sub-lethal dose presents restoration of pyruvate dehydrogenase ...
Guevara1,*, Luying Yang1,*, Barbara Birkaya2, Jieyu Zhou1, Natalia S. Nemeria1, Mulchand S. Patel2 & Frank Jordan1 The human pyruvate dehydrogenase complex (PDC) comprises four multidomain components, E1, E3, E2 and an E3-binding protein (E3BP), the latter two...
Pyruvate Dehydrogenase Kinase (PDK): An attractive target for anticancer therapyCancer cells are highly dependent on glycolysis. which provides protection ... Madhok,B Madanmohan - 《University of Leeds》 被引量: 3发表: 2012年 Implications of tempol in pyruvate dehydrogenase kinase 3 targeted antican...