Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. Prog Nucleic Acid Res Mol Biol. 2001; 70 :33–75.Roche TE, Baker JC, Yan YH, Hiromasa Y, Gong XM, Peng T, Dong JC, Turkan A, Kasten SA. Distinct regulatory properties of pyruvate dehydrogenase kinase ...
Yan et al., "Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms," Progress in Nucleic Acid Research and Molecular Biology, vol. Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer Examples include hepatic ...
& Wu, P. Regulation of the activity of the pyruvate dehydrogenase complex. Adv. Enzym. Reg. 42, 249–259 (2002). Article CAS Google Scholar Roche, T. E. et al. Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. Prog. Nucleic Acid. Res. Mol. Biol....
Phosphorylation occurs by an ATP-specific pyruvate dehydrogenase kinase at three serine residues of the α-subunit of the enzyme and leads to inactivation. The kinase is activated by elevated [acetyl-CoA]/[CoA], [NADH]/[NAD+], and [ATP]/[ADP] and inhibited by increases in [pyruvate], ...
Peptides derived from pyruvate dehydrogenase as substrates for pyruvate dehydrogenase kinase and phosphatase. Evidence is presented that phosphopeptides produced by tryptic digestion of phosphorylated pyruvate dehydrogenase are effective substrates for pyruvate deh... PF Davis,FH Pettit,LJ Reed - 《Biochemical...
Regulation of heart muscle pyruvate dehydrogenase kinase. 1. The activity of pig heart pyruvate dehydrogenase kinase was assayed by the incorporation of [(32)P]phosphate from [gamma-(32)P]ATP into the dehydrogenase complex. There was a very close correlation between this incorporation and the l....
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PDH is reversibly regulated by phosphorylation, with upregulation of pyruvate dehydrogenase kinase (PDK) and/or downregulation of pyruvate dehydrogenase phosphatase (PDP) acting as direct negative regulatory mechanisms for PDH activity. Therefore, to test whether inhibition of PDH in TAZ-KO cells results...
tricarboxylicacidcycleforoxidation.Duringexercise,pyruvatedehydrogenaseactivationinhumanskeletalmuscleisproportionalto therelativeaerobicpoweroutput(percentV ˙ O 2 max)andisregulatedbyincreasesinCa 2 ,freeADP,andpyruvateconcentrations. Keywords:carbohydrateoxidation,mitochondrion,PDHkinase,PDHphosphatase ...
Peptides derived from pyruvate dehydrogenase as substrates for pyruvate dehydrogenase kinase and phosphatase. Davis PF, Pettit FH, Reed LJ (1977) Peptides derived from pyruvate dehydrogenase as substrates for pyruvate dehydrogenase kinase and phosphatase. Biochem ... PF Davis,FH Pettit,LJ Reed - 《...