Pyruvate carboxylase is a metabolic enzyme that fuels the tricarboxylic acid cycle with one of its intermediates and also participates in the first step of gluconeogenesis. This large enzyme is multifdoi:10.1007/978-3-319-46503-6_11Mikel Valle...
Previous studies have shown that pyruvate carboxylase (PC) plays a key role in the occurrence and progression of thyroid cancer (TC); however, the relationship between PC and iodine-refractory TC is unclear. Therefore, the present study aimed to investigate the molecular mechanism of PC in the ...
Structure, mechanism and regulation of pyruvate carboxylase Pyruvate carboxylase (PC; EC 6.4.1.1), a member of the biotin-dependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetat... S Jitrapakdee,JC Wallace - 《Biochemical Journal》 被引量: 437发表: 2008年...
Pyruvate carboxylase is an enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is used in various metabolic processes such as gluconeogenesis, amino acid biosynthesis, and fat metabolism. It belongs to the family of biotin-dependent carboxylases and is present in many organisms,...
In silico modeling was used to map former and novel variants associated to type A and C PCD, and to predict their potential effects on the enzyme structure and function. We found that variants lead to type A or type C phenotype based on the destabilization between the two major enzyme ...
that impact on myocardial structure and function, at least some of their therapeutic actions are likely via a direct impact on cardiomyocytes, correcting the metabolic and contractile dysfunction that arises as a result of decreased MPC expression during stress that culminates in hypertrophy and ...
The present study evaluated the effects of exercise training on pyruvate carboxylase protein (PCB) levels in hepatic tissue and glucose homeostasis control in obese mice. Swiss mice were distributed into three groups: control mice (CTL), fed a standard rodent chow; diet-induced obesity (DIO), fe...
The present study evaluated the effects of exercise training on pyruvate carboxylase protein (PCB) levels in hepatic tissue and glucose homeostasis control in obese mice. Swiss mice were distributed into three groups: control mice (CTL), fed a standard rodent chow; diet-induced obesity (DIO), fe...
Leong and R.W. Brownsey and J.E. Kulpa and M.F. Allard 摘要: Cardiac hypertrophy, induced by chronic pressure or volume overload, is associated with abnormalities in energy metabolism as well as characteristic increases in muscle mass and alterations in the structure of the heart. ...
Pyruvate Carboxylase PCis found in the mitochondria and catalyzes the following reaction: +CO2+ATP→oxalacetate+ADP+Pi PC is a multisubunitenzymethat has acetylCoAas a positive allosteric regulator. The enzyme is critical for bothgluconeogenesisandfatty acid synthesis, since it provides oxalacetate wh...