GSEA and KEGG enrichment analyses on key module genes derived from WGCNA revealed a close association between UC and pyroptosis. Then, a total of 20 pyroptosis-related DEGs of UC and 27 pyroptosis-related DEGs of active UC were screened. Next, 6 candidate genes (ZBP1, AIM2, IL1尾, CASP1...
KEGG: Kyoto Encyclopedia of Genes and Genomes PGD2: Prostaglandin D2 STRING: Search Tool for the Retrieval of Interacting Genes References Sagoo MK, Gnudi L. Diabetic nephropathy: an overview. Methods Mol Biol. 2020;2067:3–7. Article CAS PubMed Google Scholar Selby NM, Taal MW. An...
j Bubble plot of the KEGG pathway analysis for differentially expressed proteins enriched in the MG@PM group compared to the control group. The colors of the nodes reflected the P-values of the designated pathways, and the sizes of the nodes indicated the number of differentially expressed ...
We performed GO and KEGG pathway analyses between the high- and low-risk groups using the GSEA algorithm. GO term enrichment analysis indicated that the high-risk group was mainly enriched in actin filament bundle, collagen catabolism pathways, collagen-containing extracellular matrix, collagen metaboli...
j Bubble plot of the KEGG pathway analysis for differentially expressed proteins enriched in the MG@PM group compared to the control group. The colors of the nodes reflected the P-values of the designated pathways, and the sizes of the nodes indicated the number of differentially expressed ...
(Fig.8A). In terms of molecular functions, the rich terms are mainly related to the cargo receptor activity and signaling receptor activator activity (Fig.8A). The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that DEGs are mainly enriched in the T cell receptor signaling ...
KEGG: Kyoto encyclopedia of genes and genomes LDH: Lactate dehydrogenase D-loop2: Mitochondrial displacement loop2 mitoROS: Mitochondrial ROS mPTP: Mitochondrial permeability transition pore mtDNA: Mitochondrial DNA ND1: NADH dehydrogenase 1 NF-κB: Nuclear factor-κB NLRP3: NOD-like recep...
KEGG: Kyoto encyclopedia of genes and genomes LDH: Lactate dehydrogenase D-loop2: Mitochondrial displacement loop2 mitoROS: Mitochondrial ROS mPTP: Mitochondrial permeability transition pore mtDNA: Mitochondrial DNA ND1: NADH dehydrogenase 1 NF-κB: Nuclear factor-κB NLRP3: NOD-like recep...
We performed the GSVA analysis on the DEGs matrix using the GSVA package [21], and selected “c2.cp.kegg.v7.4.symbols.gmt” as the reference gene set. Moreover, the limma package was used for differential pathway screening, and p < 0.05 was set as the screening threshold. ...
(KEGG) pathways associated with PRDX1-correlated genes (Fig.5B). These visualizations revealed that PRDX1-correlated genes predominantly participate in oxidative stress and ROS-related biological processes and signaling pathways. Previous research has established that Prdx1 is involved in cellular ...