PYROGENSThe test consists of measuring the rise in body temperatureevoked in rabbits by the intravenous injection of a sterilesolution of the substance to be examined.Selection of animals. Use healthy, adult rabbits of either sexweighing not less than 1.5 kg, fed a complete and balanceddiet not...
The endogenous pyrogens in host-defense interactions. 来自 Semantic Scholar 喜欢 0 阅读量: 53 作者:Dinarello,A Charles 摘要: Soluble factors produced by activated macrophages serve to marshal host defenses against infection, injury, or inflammation, but they may also cause chronic inflammation or ...
6. The changes in heart rate, body temperature and gastric motility induced by i. v. administration of LPS, however, do not resemble those which follow i. v. injection of NDV or johnin. Therefore LPS seems to possess other toxic properties which seem unrelated to hypersensitivity. ...
In combination of moderate and extreme whole body hyperthermia with chemotherapy, radiotherapy or immunotherapy with monoclonal antibodies significant improvement in outcome of the treatment of cancer patients is to be expected. The toxicities of active “fever therapy” or passive “fever-range whole ...