What does it mean by purines have 2 rings and pyrimidines have 1 ring? Nucleotides Nucleotides are the basic building blocks of nucleic acids; DNA and RNA. There are two different kinds of nucleotides; purines and pyrimidines, which di...
Biginelli-type heterocyclic compounds are particularly important due to their several chemical reactivities and various range of pharmacological activity. Therefore Biginelli reaction has witnessed several modification and numerous investigations are con
Extensive studies have focused on amidine reactions with coupling partners such as 1,3-dicarbonyl derivatives, α,β-unsaturated ketones, alkynones, 1,2,3-triazines28, and alcohols in the presence of organometallic catalysts based on Ir29, Ru30, Re31, Mn32,33, and Ni34. However, most of ...
Various different crystal structures were found for four mesogenic diphenylpyrimidines with two chiral centres and these have been compared with the previously determined crystal structure of 2-{4-[(R)-2-fluorohexyloxy]phenyl}-5-{4-[(S)-2-fluoro-2-methyldecanoyloxy]phenyl}pyrimidine (1) which...
Adenine and guanine are , and have rings of nitrogen carbon atoms. A) pyrimidines, double B) purines, double C) pyrimidines, single D) purines, singleBecause of base pairing in DNA, the percentage of: a. Adenine mol...
A and G are classified aspurines, while C and T arepyrimidines. Purines include a six-member ring fused to a five-member ring, and between them, these rings include four nitrogen atoms and five carbon atoms. Pyrimidines have only a six-member ring, which houses two nitrogen atoms and ...
Conclusion. In conclusion, we have represented a Michael-addition-cyclocondensation reaction between α-azidochalcones and 3-aminopyrazoles to prepare a novel library of fully substituted pyrazolo[1,5-a]pyrimi- dines and evaluated their α-glucosidase activities. Providing an efficient, simple ...
Triazolopyrimidines (TZPs) are a well-known scaffold in medicinal chemistry, and their utility is exemplified by the discovery and development of novel agents to fight a wide range of diseases. For example, TZPs possess anticancer activity,2 and have been used as phosphodiesterase inhibitors for...
The compounds of the invention have a structure according to Formula I: in which, R1 represents a member selected from substituted or unsubstituted (C1–C6)alkyl, (C1–C6)alkoxy and halogen. The symbol R2 represents a member selected from substituted or unsubstituted aryl, substituted or unsubs...
More particularly, the present invention relates to heteroalkyl linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as ...