Pyrimidines ensure correct pairing with Purines in the DNA structure. 6 Purines Involved in various biological reactions beyond nucleic acid formation. Purines are also precursors to several bioactive molecules. 6 Pyrimidines Have their synthesis and breakdown pathways. Disruption in Pyrimidines' metabo...
A family of pyrazolo[3,4-d]pyrimidine derivatives (SPPs) with different substituents on the pyrimidine and pyrazolo rings have been characterized with a panel of tests demonstrating their effects in cell proliferation, toxicity, apoptosis and inhibition of virus replication. We have identified compounds...
wherein said heterocyclic has one or more heteroatoms in one or more rings, wherein each heteroatom is independently selected from the group consisting of nitrogen, oxygen, sulfur, selenium, and phosphorus, and wherein each ring has from 3 to 10 atoms; C3-10 cycloalkoxy; C3-10 cycloalkyl-...
DFT calculations have been carried out. Considering that polar solventtert-amyl alcohol (t-AmOH) was used and sodium ions exist in the reaction solution, a reaction mediated by sodium hydroxide instead of Zundel anion38or hydroxide ion39was proposed during DFT calculations (Fig.5). In fact, so...
For a long time, relatively little attention has been paid to their fused rings that is oxazolopyrimidines, whose chemical structure is similar to that of natural purines because probably none of these compounds were found in natural products or their biological activities turned out to be ...
A and G are classified aspurines, while C and T arepyrimidines. Purines include a six-member ring fused to a five-member ring, and between them, these rings include four nitrogen atoms and five carbon atoms. Pyrimidines have only a six-member ring, which houses two nitrogen atoms and ...
or their salts, or their complexes with metal salts, characterized in that the compound of the general formula II where R and R have the indicated meanings and-2 are halogens or alkythio, or y is an amino group, and Z is an alkoxy or alkythio group, is reacted with a diamine of ...
Adenine and guanine are , and have rings of nitrogen carbon atoms. A) pyrimidines, double B) purines, double C) pyrimidines, single D) purines, singleBecause of base pairing in DNA, the percentage of: a. Adenine mol...
wherein the groups A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 have the meanings given in the claims and description, the isomers thereof, processes for preparing these pyrimidines and their use as pharmaceutical compositions. BACKGROUND TO THE INVENTION Tumour cells wholly or partly elude ...
Many reports have demonstrated that both the coactivator, cyclin E, and the inhibitor, p27, of CDK2 are either over—or underexposed, respectively, in breast, colon, nonsmall cell lung, gastric, prostate, bladder, non-Hodgkin's lymphoma, ovarian, and other cancers. Their altered expression ...