2) showed promising inhibitory effects toward several protein kinases, especially against single and double mutant EGFR tyrosine kinases (EGFRL858R, EGFRT790M/L858R) with 62–89% inhibition in enzymatic assays [38]. Indole-pyrimidine derivatives were designed using in silico study and evaluated as ...
These dihydrocyclazines are assigned the 3,4-dihydro-, 342, or the 5,7a-dihydro-structure 343, either of which may result from the original cycloadduct by double bond migration (double hydrogen shift). Compound 383, which is formally the dione tautomer of a diazadihydrocyclazinediol, is ...
Anti-Cyclobutane Pyrimidine Dimers (CPDs) mAb (Clone TDM-2) CPDs抗体 品牌:Cosmo Bio CAS No.: 储存条件:-20℃ 纯度:– 产品编号 (生产商编号) 等级规格运输包装零售价(RMB)库存情况参考值 CAC-NM-DND-001 –1 Vial–咨询–– * 干冰运输、大包装及大批量的产品需酌情添加运输费用 ...
It is further appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, can also be provided in combination in a single embodiment. Conversely, various features of the invention which are, for brevity, described in the context of...
Sequence-specific photomodification of single-stranded and double-stranded DNA fragments by oligonucleotide perfluoroarylazide derivative. A highly efficient, sequence-specific photomodification of single-stranded (ss) and double-stranded (ds) DNA fragments was carried out with a hexadecathymi... A Levi...
C1-4 alkyl or a group COR<2> wherein R<2> is hydrogen, C1-4 alkoxy or amino @@@<2> is a six-membered ring containing a nitrogen atom; @@@<3> is a six-membered ring optionally containing a nitrogen atom and the dotted lines represent single or double bonds, have antimicrobial act...
Also significant, the data inTable 1indicate Pyrp·Ni2+·Pyrpis as stabilizing to a double helix as C·G (41.2versus40.2 °C). Finally, in control experiments, essentially no effect was observed onTmvalues of the T/A or C/G duplexes when ...
The following abbreviations are used: s, singlet; d, doublet; t, triplet; q, quartet; qu, quintuplet; m, muiliplet and br, broad. Mass spectra were obtained using a Waters 2795 single quadrupole mass spectrometer with electrospray ionization (ESI). Microwave assisted chemistry was carried ...
(Fig. 1A). NEIL2 repairs the same lesions also by β,δ-elimination, but preferably in single-stranded rather than double-stranded DNA[77,78]. NEIL3 excises thehydantoinsSp and Gh, as well as oxidized pyrimidines (with lower efficiencies) and cleaves the remainingAP sitevia β-elimination...
Overall, 268 displayed suitable, low single-digit nanomolar potency toward JAK2 (IC50 = 3.9 nM) and good on-target cellular potency (STAT3 (IL-6), IC50 = 162 nM), excellent aqueous solubility (24,904 μM), minimal off-target kinase activity (S(35) = 0.055), and no observable ...