1978. Pyrimidine dimers in DNA strands of mammalian cells synthesized after UV-irradiation. In DNA Repair Mechanisms. P. C. Hanawalt, E. C. Friedberg, and C. F. Fox, editors. Academic Press, Inc., New York. 493-498.Meneghini, R., Menck, C.F.M.: Pyrimidine dimer in DNA strands ...
1973. The formation of pyrimidine dimers in the DNA of fungi and bacteria. Biochim Biophys Acta 312:626-632.Unrau P, Wheatcroft R, Cox B, Olive T. The formation of pyrimidine dimers in the DNA of fungi and bacteria . Biochim Biophys Acta . 1973; 312 : 626–632....
These studies demonstrate that DNA is the major target of UV radiation in the generation of systemic immunosuppression and suggest that the primary molecular event mediating these types of immunosuppression by UV radiation is the formation of pyrimidine dimers. Furthermore, they illustrate that the ...
Cross-linked adjacent pyrimidines (thymidine or cytidine) in DNA causing a distortion in the strand involved and thus interfering with proper functions (see Fig. P178). It is induced by short-wavelength UV irradiation. The thymidine dimers may be split by visible light-inducible enzymatic repair...
We investigated whether people who have developed basal cell carcinoma on sun-exposed skin have an altered ability to repair UV-induced pyrimidine dimers in DNA. Twenty-two patients with at least one basal cell carcinoma, aged 31-84 years, and 19 healthy volunteers, aged 25-61 years, took ...
The mechanistic study combining photochemical and photobiological techniques shows that irradiation of 5-formyluracil leads to a triplet excited state capable of sensitizing formation of cyclobutane pyrimidine dimers in DNA via a triplet–triplet energy transfer. This demonstrates for the first time that ...
UV dimer formation requires an unwinding of the DNA to a twist angle of 0°, when two bases are fused by a cyclobutane bond. Moreover, DNA containing pyrimidine dimers is kinked or bent (see Figure 2.13). Presumably the flexibility in twisting and bending DNA that is required to facilitate...
— DNA photolyases photorepair pyrimidine dimers (PyroPyr) in DNA as well as RNA and thus reverse the harmful effects of UV-A (320–400 nm) and UV-B (280–320 nm) radiations. Photolyases from various organisms have been found to contain two noncovalently bound cofactors; one is a full...
DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome... In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants. ...
As photoreactivating enzyme is specific for the repair of pyrimidine dimers in DNA, these findings support the hypothesis that these are critical lesions ... BS Rosenstein,RB Setlow - 《Photochemistry & Photobiology》 被引量: 285发表: 1980年 Repair of UV damage in actively transcribed ribosomal ...