NEW MATERIAL:The compound of formula I [R1 and R2 are aliphatic hydrocarbon group; R3 and R4 are H, alkyl or acyl; R5 is alkyl, alkoxyalkyl or formyl; the dotted line means that the pyrazole ring contains two double bonds]. EXAMPLE:3-Amino-5,7-diethyl-1-methylpyrazolo[ 3,4-d ]...
4-Aminopyrazolo-pyrimidine decorated with N-acrylamido-piperidine was chosen as a core structure to provide hinge-binding at the ATP binding site of EGFR. Also, the effects of different bicyclic lipophilic moieties at C-3 position of pyrazole ring were assessed. The biological evaluation showed ...
2 2,4,5,6-Tetraaminopyrimidine 1 (2.5 g, 14 mmol) in MeOH (12 mL) and HOAc (12 mL) was treated with NaCN (1.5 g, 30 mmol) in water (6 mL) and phenylpropargyl aldehyde 2 (2.5 g, 19 mmol) in MeOH (3 mL). After 10 min stirring and boiling, cooling deposited yellow ...
The invention relates to compounds of formula (I) and related compounds and their use in the treatment of cancer, especially platinum resistant cancer. The invention also provides a
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15 13010-20-3 N-NITROSOUREA N-NITROSOUREA CH3N3O2 16 13010-26-9 Acetamide, N-[4-[[4-[[(3,5-dichloro-2-hydroxyphenyl)methylene]amino]phenyl]sulfonyl]phenyl]- Acetamide, N-[4-[[4-[[(3,5-dichloro-2-hydroxyphenyl)methylene]amino]phenyl]sulfonyl]phenyl]- C21H16Cl2N2O4S 17 13010-31...
pyrazole derivativesring closure reactionsstructure‐activity relationshipThe synthesis of a series of 3-aryl pyrazolo[4,3-d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring...
A solution of 3-aminopyrazole (2.0 g, 24.07 mmol) and ethyl benzoylacetate (4.58 mL, 1.1 eq.) in AcOH (15 mL) was heated at reflux for 3 hours. The reaction mixture was cooled to room temperature and concentrated in vacuo. The resulting solid was diluted with EtOAc and filtered to gi...
pyrazolepyrazolo[3,4-d]pyrimidinepyrazolo-[4,3-e]-[1,2,4]triazolo[4,3-c]pyrimidineA novel -enaminonitrile of 1-(6-p-tolyl-pyridazin-3-yl)-pyrazole derivative 2 was formed using (6-p-tolyl-pyridazin-3-yl)-hydrazine ( 1 ) and 2-ethoxymethylenemalononitrile. The -enaminonitrile ...
(s), an amino group which may have a substituent(s), a carboxyl group, an alkoxycarbonyl group which may have a substituent(s), a carbamoyl group which may have a substituent(s), a nitro group, a cyano group, a trifluoromethyl group, a sulfonic acid group, a sulfonamido group which ...