NEW MATERIAL:The compound of formula I [R1 and R2 are aliphatic hydrocarbon group; R3 and R4 are H, alkyl or acyl; R5 is alkyl, alkoxyalkyl or formyl; the dotted line means that the pyrazole ring contains two double bonds]. EXAMPLE:3-Amino-5,7-diethyl-1-methylpyrazolo[ 3,4-d ]...
Furukawa Y, Maki Y, (1986) 3-Aminopyrazolo[3,4-d]pyrimidine derivatives and production thereof. US Patent 4,603,203Furukawa, Y.; Maki, Y. 3-Aminopyrazolo[3,4-d]pyrimidine Derivatives and Production Thereof. U.S. Patent Number 4,603,203, 29 July 1986....
The discovery of 1-{(3R,4R)-3-[({5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)-amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one 30 (PF-06459988) (Fig. 6) was reported by Cheng et al. in 2016 as potent and irreversible inhibitor of...
Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)- Zanubrutinib Impurity 4 Zanubrutinib Impurity 11 3-(4-(3-carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic acid ...
New aminopyrazolo[1,5- a ]pyrimidines, pyrazolo[3,4- d ]pyrimidines and imidazo[1,2- b ]pyrazoles were synthesised from ethyl 3,5-diaminopyrazole-4-carboxy... N. S. IBRAHIM,K. U. SADEK,F. A. ABDEL‐AL - 《Archiv Der Pharmazie》 被引量: 21发表: 2010年 SUBSTITUTED PYRAZOLOPYRI...
((S)-2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide) 4-acryloyl-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
Through literature review, the reaction of α-azidochalcones 1 with 3-aminopyrazoles 2 to produce this scaf- fold has not proposed yet. Considering the significant mentioned roles in drug discovery process, synthesis of new derivatives of this scaffold is of increasing importance in medicinal ...
6-Amino-3-methyl-4-(4-nitrophenyl)-2,4-dihydropyrano[2,3- c ]pyrazole-5-carbonitrile ( 1 ) was used as a precursor for preparation of some novel 3,7-dimeth... AH Shamroukh,ME Zaki,EM Morsy,... - 《Archiv Der Pharmazie》 被引量: 58发表: 2010年 Pyrazolo[4,3-d]pyrimidines ...
2,4,7-Triamino-6-phenylethynyl-pteridine (4).22,4,5,6-Tetraaminopyrimidine1(2.5 g, 14 mmol) in MeOH (12 mL) and HOAc (12 mL) was treated with NaCN (1.5 g, 30 mmol) in water (6 mL) and phenylpropargyl aldehyde2(2.5 g, 19 mmol) in MeOH (3 mL). After 10 min stirring ...
4-PHENOXYBENZOIC ACID 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (R)-Zanubrutinib tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl...