NEW MATERIAL:The compound of formula I [R1 and R2 are aliphatic hydrocarbon group; R3 and R4 are H, alkyl or acyl; R5 is alkyl, alkoxyalkyl or formyl; the dotted line means that the pyrazole ring contains two double bonds]. EXAMPLE:3-Amino-5,7-diethyl-1-methylpyrazolo[ 3,4-d ]...
Furukawa Y, Maki Y, (1986) 3-Aminopyrazolo[3,4-d]pyrimidine derivatives and production thereof. US Patent 4,603,203Furukawa, Y.; Maki, Y. 3-Aminopyrazolo[3,4-d]pyrimidine Derivatives and Production Thereof. U.S. Patent Number 4,603,203, 29 July 1986....
The discovery of 1-{(3R,4R)-3-[({5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)-amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one 30 (PF-06459988) (Fig. 6) was reported by Cheng et al. in 2016 as potent and irreversible inhibitor of...
Treatment of amino pyrazole derivative with acetic anhydride produced pyrazolopyrimidines which on after treatment with ethyl chloroacetate produced ethyl 2-(3,6-dimethyl-4-oxo-1-phenyl-1H-pyrazolo [3,4-d]pyrimidin-5(4H)-yl) acetate. The synthesized compounds were screened for their cyt...
1,3-Dimethyluracil ( 1 ), a versatile synthon for the synthesis of various heterocycles, reacted readily with 3-aminopyrazoles 2 in sodium ethoxide to give... CK Chu,JJ Suh,M Mesbah,... - 《Cheminform》 被引量: 125发表: 2010年 Synthesis of new substituted pyrazolo[1,5-a]-pyrimidine...
We report the synthesis of new anti-inflammatory 1,7-dihydropyrazolo[3′,4′:4,5]pyrimido[1,6-a]pyrimidine 5 from aminocyanopyrazole. All compounds were ch... A Karoui,F Allouche,M Deghrigue,... - 《Medicinal Chemistry Research》 被引量: 15发表: 2014年 One pot synthesis of spiro...
4-Aminopyrazolo-pyrimidine decorated with N-acrylamido-piperidine was chosen as a core structure to provide hinge-binding at the ATP binding site of EGFR. Also, the effects of different bicyclic lipophilic moieties at C-3 position of pyrazole ring were assessed. The biological evaluation showed ...
4. The process of claim 3, wherein at least one 3-aminopyrazole-4-carboxamide of Formula (2) is cyclized with at least one of an alkyl orthoformate and a mixture of formic acid and acetic anhydride. 5. The process for the preparation of the compound of claim 1 where X is sulfur, wh...
Novel 4(3H)-Quinazolinone Containing Biologically Active Thiazole, Pyrazole, 1,3-dithiazole, Pyridine, Chromene, Pyrazolopyrimidine and Pyranochromene of Expected Biological Activity 2 Abstract: Diazotization of 2-cyano-N-(6-iodo-2-methyl-4-oxoquinazolin-3(4H)-yl) acetamide 2 with the desired ...
A. Abd Al-Wahab, "Studies on aminopyrazoles: antibacterial activity of some novel pyrazolo[1,5-a]pyrimidines containing sulfon- ... SA M.,El-Gaby,and,... - 《IL Farmaco》 被引量: 84发表: 2000年 Synthesis and in vitro cytotoxic activity of novel pyrazolo[3,4-d]pyrimidines and ...