Antiarteriosclerotic and cardiac hypertrophy-inhibitory effects and influence on autonomic nervous activity. Arzneimittelforschung. 2007;57(11):698–704. doi:10.1055/s-0031-1296670 86. Minami J, Numabe A, Andoh N, et al. Comparison of once-daily nifedipine controlled-release ...
pylori, is not possible, due to diarrhea, nausea and side effects on central nervous system it causes, bismuth subcitrate is not approved as an antiulcer drug in Japan, side effects caused by the multiple drug therapy are frequently found, antibacterial drugs used for the multiple drug therapy...
proteinuria, coronary thrombosis from atherosclerotic plaque, aneurismal aortic, birth control, dystrophobic epidermolysis bullosa, degenerative cartilage loss following traumatic joint injury, osteopenias mediated by MMP activity, tempero mandibular joint disease or demyelating disease of the nervous system....
ularlyintheimmunesystem.7Thereisalsoincreasingrecent evidenceofCB2receptorexpressionintheCNS.8Whilststimula- tionoftheCB1receptormediatesanalgesia,9thisreceptoralso mediatesotherundesirableCNSside-effects.10CB2agonists,on theotherhand,haveshownefficacyinpreclinicalmodelsof ...
However, said BDZ derivatives show sometimes various side effects such as dizziness, sleepiness or the like. On the other hand, non-BDZ compounds nowadays under development have also drawbacks such as poor solubility and absorption. Accordingly, there has been a strong desire for development of nov...
Besides the side effects, the development of tolerance is one of the crucial disadvantages of this mode of treatment. Some substances which directly stimulate soluble guanylate cyclase, i.e. without previous release of NO, have been described in recent years, such as, for example, 3-(5′-...
These drugs have several disadvantages: (1) their cost is prohibitively high; (2) they are unavailable for oral administration (some of them like amphotericin B can only be used intravenously); and/or (3) they may cause serious side effects that require close monitoring of the patients (...
(cancer in the mouth area and on lips), cancer of the central nervous system, liver cancer, liver metastases, leukemia, eyelid tumor, lung cancer, lymph node cancer (Hodgkin's/Non-Hodgkin's lymphomas), lymphomas, stomach cancer, malignant melanoma, malignant neoplasia, malignant tumors ...
bladder carcinoma; liver carcinoma and biliary passages; kidney carcinoma; myeloid disorders; lymphoid disorders, Hodgkin's, hairy cells; buccal cavity and pharynx (oral), lip, tongue, mouth, pharynx; small intestine; colon-rectum, large intestine, rectum; brain and central nervous system; and leu...
Toxicity and non-selectivity of ligands for the various 5-HT receptors remain a challenge. It is suspected that the non-selectivity of some ligands contributes to various adverse side effects such as hallucinations and cardiovascular complications. Therefore, there remains a need for 5-HT2cselective ...