A compound having the formula and pharmaceutically acceptable salts thereof, are CGMPPDE selective inhibitors useful in the treatment of cardiovascular diseases, such as angina, hypertension, heart failure and atherosclerosis. 式中R Wherein RCN安德鲁·S·贝尔...
Pyrazolopyrimidinone antianginal agents United States Patent 5250534 Abstract: Compounds of the formula: ##STR1## wherein R1is H, C1-C3alkyl, C3-C5cycloalkyl or C1-C3perfluoroalkyl; R2is H, C1-C6alkyl optionally substituted by OH, C1-C3alkoxy or C3-C6cycloalkyl, or C1-C3perfluoroalkyl; ...
Pyrazolopyrimidinone antianginal agents[P].US:5426107,.A.S. Bell, K.N. Terrett, Pyrazolopyrimidinone ... AS Bell,D Brown,NK Terrett - US 被引量: 629发表: 1994年 Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents Intermediates useful in the synthesis of pyrazolo...
5719283 Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents 1998-02-17 Bell et al. 544/262 5426107 Pyrazolopyrimidinone antianginal agents 1995-06-20 Bell et al. 514/234.2 5346901 Pyrazolopyrimidinone antianginal agents 1994-09-13 Bell et al. 514/258 5272147 Pyrazolo...
Terrett, Pyrazolopyrimidinone Antianginal Agents, Pfizer Inc., 1993, US5250534.US Patent 5250534 A, Andrew SB, et al., Pyrazolopyrimidinone antianginal agents, 1993 Oct-5A.S. Bell, K.N. Terrett, Pyrazolopyrimidinone antianginal agents, European Patent 0526004 (1993), p. A1....
Terrett, Pyrazolopyrimidinone antianginal agents, Pfizer Research and Development Company, USP005250534, 1993.A.S.S Bell, D. Brown, N.K. Terrett, Pyrazolopyrimidinone Antianginal Agents, Pfizer Inc., 1993, US5250534.US Patent 5250534 A, Andrew SB, et al., Pyrazolopyrimidinone antianginal ...
R7 IS H OR C1-C4 ALKYL; 8 IS C1-C3 ALKYL OPTIONALLY WITH NR5R6; C1-C3 ALKYL OPTIONALLY SUBSTITUTED WITH PHENYL; HYDROXY C2-C3 ALKYL; OR C1-C4 ALKANOYL:ARE SELECTIVE OGMP PDE INHIBITORS USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISORDERS SUCH AS ANGINA, HYPERTENSION.HEART FAILURE AND ATHER...
Terrett, Pyrazolopyrimidinone antianginal agents, Pfizer Research and Development Company, USP005250534, 1993.A.S.S Bell, D. Brown, N.K. Terrett, Pyrazolopyrimidinone Antianginal Agents, Pfizer Inc., 1993, US5250534.US Patent 5250534 A, Andrew SB, et al., Pyrazolopyrimidinone antianginal ...
Pyrazolopyrimidinone antianginal agents 本发明有关于制造一系列吡唑并[4,3-d]嘧啶-7-酮类化合物的方法,其中所述的化合物它们是3′,5'-环磷酸鸟苷磷酸二酯酶(cGMP PDE)的强有力的和选择性的抑制剂,可应用于许... A·S·贝尔,N·K·特列特 被引量: 356发表: 1993年 PYRAZOLOPYRIMIDINONES FOR THE TR...
Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents 来自 FreePatentsOnline 喜欢 0 阅读量: 10 作者: AS Bell,D Brown,NK Terrett 展开 摘要: Compounds of the formula ##STR1## wherein Ris H, C-Calkyl, C-Ccycloalkyl or C-Cperfluoroalkyl; 展开 DOI: US...