ChemInform Abstract: Pyrazolo(3,4-d)pyrimidines; Adenosine Receptor Selectivityfused pyrimidine derivativespharmacology, medicinal chemistry, vaccines, serumsChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a...
Sznaidman.Guanine, Pyrazolo[3,4-d]pyrimidine, and Triazolo[4,5-d]pyrimidine (8-Azaguanine) Phosphonate Acyclic Derivatives as Inhibitors of Purine Nucleoside Phosphorylase.Journal of Medicinal Chemistry. 1996Beauchamp, L. M., Tuttle, J. V., Rodriguez, M. E., and Sznaidman, M. L., " ...
The select adenosine A 2A antagonist, 5-amino-7-(phenylethyl)-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c] pyrimidine (SCH 58261) failed... PT Phelps,JC Anthes,CC Correll - 《European Journal of Pharmacology》 被引量: 47发表: 2006年 ...
- 《Journal of Heterocyclic Chemistry》 被引量: 44发表: 2010年 ChemInform Abstract: A Facile Method for the Synthesis of Novel Fluorinated Pyrido [2′,3′:3,4] Pyrazolo [1,5-a] Pyrimidines. ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was ...
New A2A adenosine receptor antagonists in the series of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines, bearing oxygenated substituents on the phenylalkyl chains on the 7-position, have been synthesized. The compounds were tested in binding and functional assays to evaluate affinity, potency...
New A2A adenosine receptor antagonists in the series of pyrazolo[4, 3-e]-1,2,4-triazolo[1,5-c]pyrimidines, bearing oxygenated substituents on the phenylalkyl chains on the 7-position, have been synthesized. The compounds were tested in binding and functional assays to evaluate affinity, poten...
Hydrochloride salt of 2-((3R,4S)-1-(5-(4-chloro-3,5-difluorophenyl)-7-((2-fluoro-6-methylphenyl)(methyl)amino)pyrazolo[1,5-a]pyrimidine-2-carbonyl)-3-metho... A salt of the compound represented by formula (1) and crystals thereof having the potential to be used as drug substance...
3, 4, or 5 substituents independently selected from RA; or R1 and R2 together with the carbon atom to which they are attached form a C3-10 cycloalkyl group or a 4-10 membered heterocycloalkyl group, each optionally substituted with 1, 2, or 3 substituents independently selected from RA;...
1. The compound 2-(4-fluorophenyl)-3-[2-(1-(S)-phenylethylamino)-pyrimidin-4-yl]-6,7-dihydro-5H-pyrazolo-[1,2-a]pyrazol-1-one or a pharmaceutically acceptable salt thereof, said compound having the formula: 2. A pharmaceutical composition comprising: a) an effective amount of the ...
25卷I期 2006.1 结构化学(JIEGOUHUAXUE) Chinese J.Stfue1.Chm. Vo1.25,No.1 l08一ll2 Synthesis,StructureandBiologicalActivitiesof 2-Methylthio一3-cyano-7-(4-meth0xypheny1)- pyrazolo[1,5.a]pyrimidine① LIMing②GUtWeiSi WENLi—Rong QUBo (CollegeofChemistryandMolecularEngineering, QingdaoUniversityof...