Estrogen pyrazoles: defining the pyrazole core structure and the orientation of substituents in the ligand binding pocket of the estrogen receptor. Bioorg Med Chem. 2001;9(1):141-50.Shaun R. Stauffer,Ying Huang,Christopher J. Coletta,Rosanna Tedesco and John A. Katzenellenbogen.Estrogen pyrazole...
both describing consistently the electronic effects and conformation of methyl and trifluoromethyl substituents with regard to the solid state geometries, it appears that 3,5-dimethylpyrazole has a classical Cs structure in the gas phase consistent with the averaged C2v structure of the crystal (dynami...
Structure-function correlations in Iron(II) tris(pyrazolyl)borate spin-state crossover complexes. Iron(II) poly(pyrazolyl)borate complexes have been investigated to determine the impact of substituent effects, intramolecular ligand distortions, and inte... DL Reger,JR Gardinier,JD Elgin,... - 《In...
Futher, the replacement of any halogen with oxazole ring caused much more reduction in activity (compound 92), whereas the introduction of a second pyrazole ring to structure instead of oxazole ring resulted in a significant enhancement in inhibitory activity. Moreover, removing 1H-pyrazol-1-yl ...
Two 1,5-diarylpyrazoles related to the antiobesity agent Rimonabant have been synthesized and their structure determined by X-ray crystallography. Compound 2, 1-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1 H-pyrazole-3-carboxylate, forms strange crystals but its only peculiarity involves ...
Francisco, MEY, Burgess, JP, George, C (2003) Structure elucidation of a novel ring-constrained biaryl pyrazole CB1 cannabinoid receptor antagonist. Magn Reson Chem. 41: pp. 265-8Francisco E N Y.Structure Elucidation of a Novel Ring-consrtained Biaryl Pyrazole CBI Cannabinoid Receptor Antagonist...
Structure–Activity Relationships in a Series of Fungicidal Pyrazole Carboxanilides Structure-activity relationship in a series of fungicidal pyrazole carboxanilides. Agric. Biol. Chem. :48 45-50.Huppatz JL, Phillips JN, Witrzens B. Structure-activity relationship in a series of fungicidal pyrazole ...
N.CSIROPhillipsCSIROBarbaraCSIROWitrzensCSIROInformaworldAgricultural & Biological Chemistryand ___. 1984. Structure-activity relationship in a series of fungicidal pyrazole carboxanilides. Agric. Biol. Chem. :48 45-50.Huppatz JL, Phillips JN, Witrzens B. Structure-activity relationship in a series...
A single-crystal X-ray structure analysis of the title copper(II) complex reveals a structure in which the copper atom is centrosymmetrically coordinated b... Nobuo,Aoi,and,... - 《Inorganica Chimica Acta》 被引量: 67发表: 1984年 Osmium(II) complexes of 2-[(arylamido)phenylazo]pyridines....
We selected an N-piperidinyl-ethyl chain as a first attempt, and introduced it at the four possible sites of substitution on the pyrazole core structure to determine the orientation that the pyrazole might adopt in the ER ligand binding pocket. Of these four, the C(5) piperidinyl-ethoxy-...