Lysyl oxidases (LOX) consist of 5 secreted enzymes that catalyze collagen cross-linking, resulting in increased tumor stroma density and facilitate immune evasion. Here, we present our findings of pan-LOX inhibition with a novel orally dosed agent (PXS-5505) in a murine model of CCA. Methods...
Pan-lysyl oxidase inhibition with Pxs-5505 decreases tumor burden and interstitial pressure of murine cholangiocarcinoma - a novel therapeutic strategy for clinical translationdoi:10.1016/j.hpb.2021.06.048P. BurchardL. RuffoloN. UllmanB. Dale