Discussion: These data suggest that PVN CRH neurons play a functional role in disrupting ovarian cyclicity and the preovulatory LH surge, and that the activity of the GnRH pulse generator remains relatively robust during diestrus but not during metestrus under chronic stress exp...
2023年7月29日,徐州医科大学麻醉学院张咏梅教授课题组在美国神经精神药理学学院官方出版物Neuropsychopharmacology (中科院一区,Top期刊)在线发表了题为“Glutamatergic and GABAergic Anteroventral BNST Projections to PVN CRH Neurons Regulate Maternal Separation-Induced Visceral Pain”的研究论文。徐州医科大学麻醉学院青...
张野团队与上海科技大学团队合作,在《Advanced Science》发表了题为“Propofol alleviates anxiety-like behaviors associated with pain by inhibiting the hyperactivity of PVNCRHneurons via GABAAreceptor β3 subunits” 的论文,揭示了单剂量异丙酚可以通过作用于GABAAβ3亚基,抑制PVNCRH神经元的过度激活,有效地重新平...
Only 12.2 +/- 0.9% of CRH neurons of the medial parvocellular neurons contained PCREB nuclei in vehicle-treated animals, whereas 30 min following NPY ... S Sumit,RM Lechan - 《Endocrinology》 被引量: 493发表: 2003年 Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical...
neurons containing oxytocin, a clear segregation was apparent, allowing for a precise anatomical description of the pattern of activated MAPK within the PVN... D Daniels,CS Patten,JD Roth,... - 《Brain Research》 被引量: 159发表: 2003年 Expression of mRNAs for vasopressin, oxytocin and cortic...
Neurons in the prefrontal cortex (PFC) can provide top-down regulation of sensory-affective experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however, remains poorly understood. Here, we examined how oxytocin (OT) signaling from the hypothalamus regulates nociceptive codin...
PVNAcute stressGABAHypothalamusOT/CRH interactions in hypothalamus modulate the neuroendocrine response to stress.Activation OTRs expressed by CRH neurons may promote direct inhibition.Activation of OTRs expressed by GABAergic neurons may increase local inhibition....
Optogenetic activation of Crh-IRES-Cre PVN neurons by cre-dependent viral expression of channelrhodopsin.Jaclyn, I. Wamsteeker CusulinTamás, FüzesiAlan, G. WattsJaideep, S. Bains
Adrenalectomy attenuated FosB/ΔFosB protein expression in the PVN CRH-positive neurons.Daniel, GarcíaPérez
We tested this hypothesis by evaluating chronic variable stress (CVS)-induced changes in total (synaptophysin), glutamatergic (VGluT2), GABAergic (GAD65), and noradrenergic (DBH) terminal immunoreactivity on PVN parvocellular neurons using immunofluorescence confocal microscopy. CVS increased the total ...