2023年7月29日,徐州医科大学麻醉学院张咏梅教授课题组在美国神经精神药理学学院官方出版物Neuropsychopharmacology (中科院一区,Top期刊)在线发表了题为“Glutamatergic and GABAergic Anteroventral BNST Projections to PVN CRH Neurons Regulate Maternal Separation-Induced Visceral Pain”的研究论文。徐州医科大学麻醉学院青...
2024年4月19日,安徽医科大学第二附属医院麻醉与围术期医学科张野团队与上海科技大学胡霁团队合作,在《Advanced Science》发表了题为“Propofol alleviates anxiety-like behaviors associated with pain by inhibiting the hyperactivity of PVNCRHneurons via GABAAreceptor β3 subunits” 的论文,揭示了单剂量异丙酚可以...
We determined the effects of DREADDs activation of PVN CRH neurons on the estrous cycles, LH pulse frequency in diestrus and metestrus and LH surge in proestrus mice. The effect of long-term C21 administration on basal corticosterone secretion and the response to acute restraint stress during met...
Neurons in the prefrontal cortex (PFC) can provide top-down regulation of sensory-affective experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however, remains poorly understood. Here, we examined how oxytocin (OT) signaling from the hypothalamus regulates nociceptive codin...
We previously reported that hypoxia activates (Fos‐immunoreactivity; IR) PVN neurons that project to the nucleus tractus solitarii (nTS). The majority of hypoxia‐activated nTS‐projecting neurons are CRH‐IR. These findings suggest that the PVN may influence chemoreflex‐evoked cardiorespiratory ...
Corticotropin-releasing hormone synthesizing neurons in the hypothalamic paraventricular nucleus of rats neonatally treated with monosodium glutamate can r... The obtained data show that in MSG-treated animals the rise in CRH mRNA in response to immobilization stress and adrenalectomy as well as the ...
The motor behavior that follows from the activation of CRH neurons is not necessarily under the control of these cells but is determined by higher order circuits that discriminate more refined features of environmental context to execute the appropriate behavior.Nuria Daviu...
Our findings suggest that PVN CRH neurons are dually regulated by functionally opposing avBNST neurons and that this circuit may be the basis for neurobiological vulnerability to visceral pain.doi:10.1038/s41386-023-01678-1Si-Ting HuangKe Wu...
PVNAcute stressGABAHypothalamusOT/CRH interactions in hypothalamus modulate the neuroendocrine response to stress.Activation OTRs expressed by CRH neurons may promote direct inhibition.Activation of OTRs expressed by GABAergic neurons may increase local inhibition....
Adrenalectomy attenuated FosB/ΔFosB protein expression in the PVN CRH-positive neurons.Daniel, GarcíaPérez