areaGeoff Burnstock's remarkable insight and tenacity has established the area of purinergic research as a bona fide target for drug discovery. While efforts in P1 receptor-based medicinal chemistry and biology efforts over the past 25 years have not reached the level of success that the ...
The chemical biology of clinically tolerated NMDA receptor antagonists Most neuroprotective drugs have failed in clinical trials because of side-effects, causing normal brain function to become compromised. A case in point con... SA Lipton,HS Chen 被引量: 0发表: 2013年 Intracellular calcium is reg...
Deoxyribonucleic acid, or DNA, may be the most famous single molecule in all of biology. The discovery of its double-helix structure in 1953 catapulted James Watson and Francis Crick a Nobel Prize, and even among non-science nerds, DNA is widely known for playing a major part in the innum...
Purine metabolism affects a broad range of cellular processes, including energy production and DNA/RNA synthesis. ATP is hydrolysed to ADP and further to AMP, thereby meeting energy demand and facilitating nucleotide assembly. Cyclic AMP (cAMP) is the omnipresent second messenger controlling cellular p...
Enrico Marinello, Brunetta Porcelli, Daniela Vannoni & Anna Taddeo Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 253A)) 160 Accesses Abstract We have already reported1 that gouty patients have a tendency to higher urinary levels excretion of purine ...
(1995). Free Oxypurines in Plasma and Urine of Gout Patients Before and After a Purine-Free Diet. In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/...
Tumor cell killing by mmol/l ATP concentrations is a long-standing observation.85,97In most cases, this effect is mediated by the P2X7R, a receptor widely expressed by cancer cells. However, against this marked outcome due to P2X7R overstimulation, it is now clear that tonic, low level, ...
Y Ning,GP Holmquist,TR O’Connor - 《Journal of Molecular Biology》 被引量: 198发表: 1998年 High resolution deletion mapping reveals frequent allelic losses at the DNA mismatch repair loci hMLH1 and hMSH3 in non-small cell lung cancer. To study the involvement of DNA mismatch repair genes ...
Heterogeneous repair of N-methylpurines at the nucleotide level in normal human cells. J Mol Biol. 1998; 284 (2):269–285. [ PubMed ]YE N ET AL: "Heterogeneous repair of N- methylpurines at the nucleotide level in normal human cells" JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. ...
doi:10.1007/978-1-4613-4223-6_78P. R. BrownUniversity of Rhode IslandA. M. KrstulovićUniversity of Rhode IslandR. A. HartwickUniversity of Rhode IslandAdv Exp Med BiolAdvances in Experimental Medicine & Biology