Structure-activity relationship of purine and pyrimidine derivatives on cyclic nucleotide phosphodiesterase activity of rat braindoi:10.1016/S0021-5198(19)66978-7Matsutaro MurakamiShiro TorninagaKatsuhiro WatanabeHikaru OzawaJapanese Journal of Pharmacology...
Purines vs. Pyrimidines While both purines and pyrimidines are heterocyclic aromatic compounds, they can be differed from each other based on the chemical structure. A purine hastwocarbon rings whereas a pyrimidine hasonecarbon ring. The purine has apyrimidine ringfused to animidazole ring. The...
www.nature.com/scientificreports OPEN received: 17 May 2016 accepted: 24 August 2016 Published: 12 October 2016 Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans Dong Ik Park1,*, Carine Dournes2,*, Inge Sillaber3, ...
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. J. Med. Chem. 42:2064-2086.HOLY ET AL: " Structure-Antiviral Activity Relationship in the Series ...
P. Theoretical and experimental studies of adenine, purine and pyrimidine isolated molecule structure. J. Mol. Struct. 1985, 131, 333-346.Stepanian S G,Sheina G G,Radchenko E D,et al. Theoretical and experimental studies of adenine,purine and pyrimidine isolated molecule structure[J]. Journal...
NP-II family includes thymidine phosphorylase (TP, EC 2.4.2.4) and pyrimidine nucleoside phosphorylase (PyNP, EC 2.4.2.2). The families differ mainly in the quaternary structures of the proteins, as well as in the active sites and favored substrates [1–3]. NPs from microorganisms we...
Molecular genetics, biochemistry and clinical aspects of purine and pyrimidine metabolism. Heidelberg: Springer; 1993. p. 54. Google Scholar Carothers AM, Urlaub G, Mucha J, Harvey RG, Chasin LA, Grunberger D. Splicing mutations in the CHO DHFR gene preferentially induced by (+/−) 3a,4b...
The three structures with purine or pyrimidine nucleotide ligands are all hexameric. Also, the binding of deoxy or ribonucleotides is similar, as in the former a water molecule replaces the hydrogen bond made by Lys11 to the 2′-hydroxyl group of the ribose moiety. This allows Lys11 to ...
Structure–activity relationship of a cold-adapted purine nucleoside phosphorylase by site-directed mutagenesis. Enzym. Microb. Technol. 2012, 51, 59–65. [Google Scholar] [CrossRef] Renata, H.; Wang, Z.J.; Arnold, F.H. Expanding the Enzyme Universe: Accessing Non-Natural Reactions by ...
Figure 2. Structure of the N-terminal ATP-binding domain of Hsp90 (Hsp90ND) complexed with various inhibitors. The cartoon presentation of Hsp90ND in complex with (A) non-purine based inhibitors alvespimycin (17-DMAG; Protein Data Bank (PDB): 1OSF, magenta) and radicicol (PDB: 1BGQ,...