US National Library of Medicine, Yasuhara “Ethnic factors in evaluation of drug efficacy and safety”, 1994. Setiabudi et al., “Dapsone N-acetylation, Metoprolol, alpha-hydroxylation, and S-mephenytoin 4-hydroxylation polymorphisms in an Indonisian population: A cocktail and extended phenotyping...
suboptimal performance is a major issue that limits their wide applicability. Circulating tumor cells (CTC) have also been established as providing outcome predictions from particular therapies; however CTCs can be detected in less than 30% of ...
For purposes of the present invention, the term “parenteral route” refers to the administration of a composition, such as a drug in a manner other than through the digestive tract. Parenteral routes include routes such as intravenous, intra-arterial, transdermal, intranasal, sub-lingual and intr...
Starting with a library containing random RNA sequences, in vitro evolution techniques allow for the selection of the RNA molecules that are able to bind a specific pre-identified substrate, such as a ligand or receptor (Ciesiolka et al., RNA 1:538-550 (1995); Klug and Famulok, ...
Highly Tumor-Specific DNA Nanostructures Discovered by in vivo Screening of a Nucleic Acid Cage Library And Their Applications in Tumor-Targeted Drug Delivery. Biomaterials 195, 1-12 (2019). Qian Liu, Dong Wang, Zhi Xu, Chunji Huang, Chun Zhang, Binfeng He, Chengde Mao, Guansong Wang & ...
To determine the number of target cells for infection and the amount of virus to use for infection, preliminary dilution experiments were carried out to mimic a library screening method. Considering the total number of kinase cDNAs in the library, dilution experiments were carried out by diluting ...