Indeed, knockdown of Bcl-XL by siRNA, but not that of cIAP1 or Mcl-1, led to a significant increase in TNF-a-induced apoptosis (Figure 5b; Supplementary Figure S4a and S4b), consistent with the previous finding that Bcl-XL is the major survival factor in colon cancer cells.15 However,...
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In addition, the survival rate and body weight loss of b-arr2 WT and b-arr2 KO mice was followed after 2% DSS induction (Supplementary Figure S2a, b). The survival of a cohort of 20 age-matched b-arr2 WT and 20 b-arr2 KO mice exposed continuously to 2% DSS in the drinking ...