Pulmonary hypertension (PH) is frequent in left heart disease (LHD), especially in heart failure with preserved ejection fraction (HFpEF). In contrast with group 1 PH, PH due to HFpEF is triggered by the underlying condition through a passive increase in left atrial pressure. A small subset ...
根据世界卫生组织(WHO)的分类,PH分为五类,其中WHO 2类肺动脉高压又称为与左心疾病相关的PH,是最常见的亚型之一。本文将重点讨论WHO 2类肺动脉高压的定义、病因、临床表现、诊断和治疗方法。 定义:WHO 2类肺动脉高压是指由于左心疾病导致的肺动脉高压。左心疾病包括各种心脏病和心血管疾病,如心肌梗死、心力衰竭...
Pulmonary hypertension is classified into five groups, depending on the cause. Group 1: Pulmonary arterial hypertension (PAH).Group 2: Pulmonary hypertension caused by left-sided heart disease.Group 3: Pulmonary hypertension caused by lung disease.Group 4: Pulmonary hypertension caused by chronic ...
Bronchopulmonary dysplasia (BPD) is a major complication in prematurely born infants. Pulmonary hypertension (PH) associated with BPD (BPD-PH) is characterized by alveolar diffusion impairment, abnormal vascular remodeling, and rarefication of pulmonary
This chapter discusses the anatomical and physiological basis for chronic pulmonary arterial hypertension and its diagnosis and management. Pulmonary arterial hypertension (PAH) can lead to significant cardiac dysfunction and is associated with an increa
AMPK has been reported to facilitate hypoxic pulmonary vasoconstriction but, paradoxically, its deficiency precipitates pulmonary hypertension. Here we show that AMPK-α1/α2 deficiency in smooth muscles promotes persistent pulmonary hypertension of the
Group 1.4.3 Porto-pulmonary hypertension Porto-pulmonary hypertension (POPH) is defined by the development of PAH associated with increased pressure in the portal circulation [33,34]. Prospective hemodynamic studies have shown that 2-6% of patients with portal hypertension had PH [35,36]. However...
PAH=pulmonary arterial hypertension. At week 24, the 6-min walk distance had increased from baseline by a mean of 35·0 m (SD 52·52) in the macitentan group versus 1·0 m (83·24) in the placebo group (least-squares mean difference 34·0 m, 95% CI 2·9–65·2, p=0·033; ...
To investigate the long-term safety of inhaled iloprost in patients with pulmonary hypertension (pH), including idiopathic PAH (IPAH group) and other forms of pulmonary hypertension (PHother). Sixty-three patients (IPAH group, n = 40, PHother n = 23) were enrolled to receive inhaled ilopros...
Ferroptosis, a nonapoptotic form of cell death that is triggered by iron-dependent lipid peroxidation and contributes to the pathogenesis of several inflammation-related diseases, but its role in pulmonary hypertension (PH) has not been studied. We examined endothelial cell ferroptosis in PH and the...