Conventionalchest radiographyreveals diffuse infiltrates, and honeycombing develops in the later stages of pulmonary fibrosis. Whenpulmonary function testsare examined, there is a decrease in lung volume, especially vital capacity (VC) andtotal lung capacity(TLC), a decrease in the gas exchange ability...
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic interstitial lung disease (ILD), characterized by replacement of the normal lung tissue by fibrotic scarring, honeycombing and increased deposition of extracellular matrix proteins within the pulmonary interstitium. IPF is an ...
viral infection, reflux, aspiration of gastrointestinal contents, and others) that leads to alveolar damage in the lungs. Researchers further hypothesize that in an attempt to repair the alveolar damage, fibrosis and lung scarring occur to produce eventually clinical pulmonary fibrosis. ...
which was known as "honeycomb lung". The pulmonary alveolar - capillaries can have asymmetrical or eccentric thickening and the pulmonary capillary bed decreases. However, IPF was pathologically free of arteritis or granuloma. In other words, connective tissue disease or other interstitial lung disease...
Pulmonary fibrosis is the end stage of a broad range of heterogeneous interstitial lung diseases and more than 200 factors contribute to it. In recent years, the relationship between virus infection and pulmonary fibrosis is getting more and more attention, especially after the outbreak of SARS-CoV...
Regardless of the etiology for restrictive lung diseases, many eventually lead to extensive fibrosis. The gross appearance, as seen here in a patient with organizing diffuse alveolar damage, is known as "honeycomb" lung because of the appearance of the irregular air spaces between bands of dense ...
Aberrant expansion of KRT5+ basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity of KRT5+ cells in IPF
Idiopathic pulmonary fibrosis (IPF) is a non-neoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known provocation. IPF is a rare disease which affects approximately 5 million persons
Pulmonary fibrosis is characterized by scarring of the lung parenchyma resulting in progressive hypoxemia and may be caused by over 200 diseases including acquired (e.g., silica dust), systemic inflammation (e.g., lupus), or genetic (e.g., cystic fibrosi
Additionally, p16INK4A+ fibroblasts and epithelial cells with telomere-associated DNA damage foci (TAFs), another marker of cellular senescence, accumulated in fibrotic regions of honeycomb lung in patients with IPF, together with increased expression of SASP components (including the matrix remodeling ...