Finally, pulmonary fibrosis is commonly associated with pulmonary hypertension and right heart failure. Conventional chest radiography reveals diffuse infiltrates, and honeycombing develops in the later stages of pulmonary fibrosis. When pulmonary function tests are examined, there is a decrease in lung ...
Idiopathic pulmonary fibrosisBronchiolar diseaseInterstitial lung diseases (ILD) comprise a heterogeneous group of disorders, and when diagnosed at the stage of pulmonary fibrosis, the underlying lung disease can sometimes be difficult to identify. The aim of the present study was to determine whether ...
honeycombingIntroduction High Resolution Computed Tomography (HRCT) plays a pivotal role in the diagnosis of Idiopathic Pulmonary Fibrosis (IPF). First, it establishes the presence of lung fibrosis. Second, it allows the recognition of specific patterns, namely typical and probable Usual Interstitial ...
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease limited to the lungs and associated with the histologic appearance of usual interstitial pneumonia (UIP) on surgical lung biopsy. The estimated prevalence in the United States is between 35,000 and 55,000 cases, and evidence ...
Here, we show that conditional deletion of the ubiquitin ligase() in lung epithelial cells in adult mice produces chronic lung disease sharing key features with IPF including progressive fibrosis and bronchiolization with increased expression of Muc5b in peripheral airways, honeycombing and ...
Fig. 2: Honeycomb lung. Dilated cystic spaces embedded within advanced fibrosis (A). The cysts are lined by ciliated respiratory epithelium and the spaces are often filled with mucous debris (B). Full size image There are three other common scenarios where a histologic diagnosis of UIP may be...
Approximately one-third of fibrosing interstitial lung diseases exhibit progressive pulmonary fibrosis (PPF), a clinicopathological condition distinct yet resembling idiopathic pulmonary fibrosis (IPF). PPF in ANCA-positive ILD (ANCA-ILD) is poorly docum
Large-scale changes in the structure and cellular makeup of the distal lung are a hallmark of pulmonary fibrosis (PF), but the spatial contexts that contribute to disease pathogenesis have remained uncertain. Using image-based spatial transcriptomics, we analyzed the gene expression of 1.6 million ...
Once established, fibrosis is irreversible and frequently progressive. Extensive tissue destruction may also occur, resulting in so-called “honeycomb” lung. Honeycomb lung is the end result of severe chronic interstitial lung disease with both fibrosis and cicatricial (“scar”) emphysema as major ...
Honeycombing with or without tractionbronchiectasis Absence of features listed as inconsistent with UIP Bronchoscopyand surgical lung biopsy are also used to help distinguish between UIP and idiopathic pulmonary fibrosis. Consequently, the newest diagnostic criteria of idiopathic pulmonary fibrosis require the...