Introduction ALI is a severe disease characterised by an excessive inflammatory response.ARDS is an acute inflammatory lung disease with more severe clinical manifestations than ALI, usually accompanied by increased alveolar permeability, causing severe alveolar oedema and further exacerbation of hypoxia, wit...
Here, we have investigated the function of pulmonary pericytes in the postnatal lung vasculature using inducible genetic experiments in mice in combination with three-dimensional imaging of thick sections at high resolution. We have made use ofPdgfrb(BAC)-CreERT2transgenic mice, which allow tamoxifen-...
Effect of Cyclooxygenase and Lipoxygenase Products on Pulmonary Function in Group B Streptococcal Sepsis1 CLEIDE SUGUIHARA, RONALD N. GOLDBERG, DOROTHY HEHRE, ALDO BANCALARI, AND EDUARDO BANCALARI Department of Pediatrics, Division of Neonatology, University of Miami School of Medicine, Miami, ...
liveL. longbeachaebut not the co-cultured non-MAIT cells (Fig.1b, c, Supplementary Fig.2). Intracellular infection of wild-type THP1 and THP1.MR1+ cell lines induced expression of tumor necrosis factor (TNF) by human MR1-5-OP-RU tetramer+ MAIT cells. Activation was related to the ...
WT C57BL/6 mice were purchased from the Jackson Laboratory (000664) and bred in our own colony. TLR2/TLR4 double knockout mice on the C57BL/6 background (backcrossed over six generations) were generated by Shizuo Akira (Osaka University) and provided to us by Lynn Hajjar (University of ...
Lemanske RF, Mauger DT, Sorkness CA, Jackson DJ, Boehmer SJ, Martinez FD, Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, Covar RA, Guilbert TW, Larsen G, Morgan WJ, Moss MH, Spahn JD, Taussig LM: Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids...
Rubin BK. Pediatric aerosol therapy: new devices and new drugs. Respir Care. 2011;56(9):1411–21. doi:10.4187/respcare.01246. discussion 21-3. PubMedGoogle Scholar Kroneberg P, Zimlich W, Muellinger B, Wenker A, Scheuch G, editors. Device output is not a predictor of lung dose. ...
(#003720) were purchased from Jackson laboratory (Bar Harbor, ME, USA) and housed in specific pathogen free conditions. Food and water were available ad libitum. Three developmental stages, namely, embryonic day (E) 18 (completion of embryonic lung development), postnatal day (P) 28 (...
E.D.L was the recipient of an “aspirant” PhD fellowship from FWO Vlaanderen. FWO Vlaanderen was not involved in study design, analysis, writing of the report or the decision to submit it for publication.Author information Authors and Affiliations Laboratory of Tissue Homeostasis and Disease, ...
(B6.129S-Tnftm1Gkl/J; Tnf-/-), and interleukin (IL)-6 (B6;129S2-Il6tm1Kopf/J; Il6-/-), and their respective wild-type mice (C57BL/6J for Tnfr+/+ and Tnf+/+; B6129SF2/J for Il6+/+; B6129PF2/J for Nfkb1+/+), were purchased from Jackson Laboratories (Bar Harbor, ...