在本工作中,研究人员利用磷脂组学分析发现,相比于Tconv细胞,Treg细胞具有优先使用PUFAs用于合成细胞膜磷脂的偏好性;当添加外源性PUFAs(如花生四烯酸)时,Treg细胞与Tconv细胞中PUFA-PLs含量的差异则进一步扩大。富含PUFA的膜磷脂更容易被...
相比之下,外源性二酰基- PUFA-PLs包括PC、PS和PG在细胞中保持相对完整(图2A和S2B)。用磷脂酶A2抑制剂处理使IGROV-1细胞对PC-PUFA2s敏感,PCPUFA2s的快速重塑明显,但与磷脂酶A2s的反应性没有降低,这导致了lysoPC的消耗(图2B)。为了阐明PC-PUFA2s的重塑,如图C所示,研究者在脂肪酰基尾部设计了氘化的PLs,而不...
phospholipids (PLs)Rice blast is one of the most devastating diseases and a serious threat to global food security. It is caused by the ascomycetous fungusdoi:10.1080/21501203.2024.2350169View further author informationhttps://orcid.org/0000-0002-3572-1559...
接下来作者定量分析了6.5细胞和7.4细胞摄取FAs的能力,发现外源增加相同FA水平时,6.5细胞累积FAs的能力比7.4细胞更强。这种差异在中性脂(NLs)、游离FAs(FFAs)暴露时比磷脂(PLs)暴露时更明显。在n-6 C20:4 (ARA)和n-3 C20:5 (EPA...
(PUFA-PLs) in the cellular membrane.2Correspondingly, ferroptosis can be blocked by inactivation of enzymes involved in PUFA-PL biosynthesis, such as ACSL4, which ligates free PUFAs with coenzyme A to produce PUFA-CoAs for their subsequent incorporation into PLs (Fig.1).2Although PUFAs are ...
3.采用多元统计分析方法,如主成分分析(PCA)、偏最小二乘回归(PLS)等,对复杂样品进行多变量分析。 方法比较与验证 1.将新方法与传统的PUFA含量测定方法进行比较,如气相色谱-质谱联用(GC-MS)等,评估新方法的优缺点。 2.通过交叉验证实验,验证新方法在不同样品类型和不同浓度下的适用性。 3.对新方法进行长期稳...
Mission: To promote consumer awareness of the evidence that PUFA overconsumption from seed oils that are wrongly promoted as healthy promote excessive oxidative
铁死亡是通过磷脂过氧化实现的,该过程依赖于过渡金属铁,ROS和含有多不饱和脂肪酸链的磷脂(PUFA-PLs)。此外,细胞代谢会通过调控ROS和PUFAs的水平调节铁死亡,多种细胞外因子也影响细胞对铁死亡的敏感性。微量营养素硒是铁死亡的一个重要调节因子,它对于生物合成一些包括谷胱甘肽过氧化物酶4(GPX4,关键的磷脂过氧化的抑制...
To our best knowledge, degumming KO has not been tested for the separation of ω-3 PUFA-rich PLs. Therefore, the primary aim of this study was to use the principles of water degumming to separate phospholipids from triglycerides in krill oil by hydration. It is hypothesized that water degummi...
Mandarine Cantonese English Japanese German Others (pls specify) Nil Number and type of Conference room: Number of Conference room: 3 Size (sqm net) Capacity View Rate (in RMB) Video Audio Web Room 1 10 5-6 No Window 120/hr No No Yes Room 2 18 8-10 With Window 240/hr Yes Yes Yes...