000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are
many of them, showing no visible wounds but utterly transformed by combat—with symptoms of involuntary trembling, irritability, restlessness, depression, nightmares, flashbacks, insomnia, emotional numbness, sensitivity to noise, and, all too often, a tendency to seek relief...
For people with post-traumatic stress disorder (PTSD), recall of traumatic memories often displays as intrusions that differ profoundly from processing of ‘regular’ negative memories. These mnemonic features fueled theories speculating a unique cogniti
The same resting-state fMRI measurement and image processing procedure as described in Misaki et al. (2018) were used in both the baseline and the post-training sessions, which is summarized here. A single-shot gradient-recalled echo-planner imaging (EPI) sequence with sensitivity encoding (SENSE...
I found these ideas about shame and becoming a therapist/healer very interesting: 'Why might excellent therapists also be shame-prone therapists? First of all, it's a matter of innate emotional sensitivity. Some babies are born needing extra regulation for an emotional response system easily over...
Additionally, there was no difference in activity response during the foot shocks, suggesting a similar sensitivity and reactivity to the shock (Figure 1d). E2/E2 mice showed a significantly slower decline in freezing over 4 days of contextual fear extinction compared with all other groups (Figure...
sensitivity to predator danger rather than a memory of specific cues, as shown by their greater responsiveness to a cue of predator danger distinct from those they were exposed to 7 days previously. “Hypervigilance” is one of the characteristic consequences of PTSD in humans12,19,20, and ...
The curve plots the true-positive rate (TPR or sensitivity) against the false-positive rate (FPR or specificity) across all thresholds (typically at selected intervals). Each point on the ROC curve corresponds to a specific sensitivity and specificity pair [32,41]. We ran an ROC curve ...
The SR-LAB calibration unit was used routinely to ensure consistent stabilimeter sensitivity between test chambers and over time. Each Plexiglas cylinder rests on a platform inside a sound-proofed, ventilated chamber. Movement inside the tube is detected by a piezoelectric accelerometer below the ...