武汉艾美捷科技有限公司生产的Human Parathyroid Hormone (1-34),中文名称【PTH(1-34)】人甲状旁腺素(1-34)英文名字HumanParathyroidHormone(1-34)供应商ProSpec产品货号HOR-29
The bone catabolic actions of parathyroid hormone (PTH) are seen in patients with hyperparathyroidism, or with infusion of PTH in rodents. We have previously shown that the chemokine, monocyte chemoattractant protein-1 (MCP-1), is a mediator of PTH’s anabolic effects on bone. To determine it...
Parathyroid Hormone 1-84 (full length) Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 84 amino acids, having an MW of ~10kDa. The PTH is purified by proprietary chromatographic techniques.
An investigational oral form ofparathyroid hormone(PTH 1-34), EB 613 (Entera Bio Ltd) met its primary efficacy outcome in a phase 2 dosing study involving postmenopausal women with low bone mineral density (BMD). The adverse effect profile of the drug was similar to that of the injectable ...
(1-34) since it represents the first 34 aa of the mature hormone, reproduces all the activity of the full length mature hormone and has been used therapeutically for treatment of osteoporosis (1-3). C-terminal peptides mainly oppose the activities of PTH (1-34) and are increased in ...
The receptor for parathyroid hormone (PTH) and PTH-related protein (PTHrP) is a G protein-coupled receptor (GPCR) that plays a key role in controlling blood Ca2+ concentration and endochondral bone formation. This review focuses on the molecular mechanisms by which the receptor recognizes the PTH...
A recent double-blind, placebo-controlled randomized phase III trial has demonstrated that replacing parathyroid hormone (PTH) with the recombinant form PTH(1–84) is safe and effective. Patients with hypoparathyroidism are currently treated with high doses of calcium and calcitriol (active vitamin ...
Vitamin D and parathyroid hormone (PTH) regulate mineral metabolism and are required to maintain calcium levels. Vitamin D deficiency is common, particularly during pregnancy, and has been associated with hypertensive disorders of pregnancy. We sought to determine whether maternal 25(OH)D, PTH and ...
Receptors Specific for the Carboxyl-Terminal Region of Parathyroid Hormone on Bone-Derived Cells: Determinants of Ligand Binding and Bioactivity PTH comprises 84 amino acids of which the first 34 are sufficient for full activation of the classical PTH/PTHrP receptor, the type 1 PTH receptor. It is...
<div p-id="p-0001">The present invention is related to novel parathyroid hormone polypeptide derivatives, and to pharmaceutical composition containing the polypeptides, as well as synthetic and recomb