The clinical course of the 5 years old boy in whom the present investigations were carried out have been reported previously (Pouillaude et al. Arch.Franc.Ped.28-1021-1971). During the hypocalcemic and hypomagne
Parathyroid hormone (PTH) plays a critical role in controlling calcium, phosphate, and calcitriol (active vitamin D) levels in the blood and bone. Through its primary actions, PTH directly involves the kidneys, bone, and other organs in maintaining key biological functions. Hypoparathyroidism (...
Elevation of (Ca2+)i of renal proximal tubule cells and down- regulation of MRNA of PTH-PTHrP, V1a and AT1 receptors in kidneys of diabetic rats. Kidney Int 1997; 51: 1950-1955.Marcinkowski W,Zhang G,Smogorzewski M,et al.Elevation of[Ca2+ ]i of renal proximal tubular cells and down...
PTH modulates bone turnover by binding to the PTH/PTH-related peptide (PTHrP) type 1 receptor (PPR), a G-protein-coupled receptor highly expressed in bone and kidneys. Osteocytes, the most abundant cells in adult bone, also express PPR. However, the physiological relevance of PPR signaling ...
1,2PTH, together with vitamin D and calcitonin, brings about mobilization ofcalcium and phosphate from the skeletal system and increases the uptakeof calcium in the intestine and the excretion of phosphate via the kidneys.The constancy of the blood calcium level is ensured by the interaction of...
Circulating intact parathyroid hormone (iPTH) levels include full-length (1-84) PTH and long C-PTH fragments, but primarily (7-84) PTH, which have been reported to have antagonistic effects on the bones and kidneys. However, their effects on the cardiovascular system remain unclear. In this ...
The main function of this hormone is to regulate plasma levels of calcium through its effect on the bones, kidneys, and intestine. The regulation of serum calcium levels is important due to the role of calcium in muscle contraction and nervous signal conduction. Answer and Ex...
We note that though RGS14 action on the kidneys and Rgs14 effects on the brain share negative regulation, they involve different RGS14–Rgs14 structural features because the modulatory action of RGS14 on NPT2A-dependent phosphate transport depends on the RGS14 PDZ element, absent in rodent Rg...
The kidneys attempt to compensate for the increased blood calcium level by secreting excess calcium in the urine, which can result in the formation of kidney stones. The effects of increased PTH levels are seen not only in the kidneys, but also in the skeleton, stomach and intestines, the ...
Parathyroid hormone is also known to accelerate the absorption of calcium in the intestine by increasing active vitamin D3 production in the kidneys (Non-patent Reference 1). A method of treating osteoporosis that increases the density of cancellous bone and does not decrease the density of the ...