Ptf1a 人类同源基因 PTF1A 品系描述 将CreERT2-WPRE-pA插入到小鼠Ptf1a基因起始密码子处。 应用领域:Cre工具鼠,胰腺多能祖细胞等区域 *使用本品系发表的文献需注明: Ptf1a-CreERT2 mice (Cat. NO. NM-KI-200118) were purchased from Shanghai Model Organisms Center,
for human pancreatic cancer, expression levels of HMGA1 in pancreata from this mouse model have not been characterised.Quantitative immunohistochemical analysis was used to determine nuclear HMGA1 levels in pancreatic tissue sections from Ptf1a-Cre; LSL-KrasG12D mice aged 5, 11, and 15 months. ...
Although the Ptf1a-Cre; LSL-KrasG12D transgenic mouse is perhaps the most widely utilised animal model for human pancreatic cancer, expression levels of HMGA1 in pancreata from this mouse model have not been characterised. Methods: Quantitative immunohistochemical analysis was used to determine ...
Significantly elevated HMGA1 levels observed in the nuclei of PanINs in Ptf1a-Cre; LSL-KrasG12D mice validate this animal model for investigating the role that HMGA1 plays in cancer progression and testing therapeutic approaches targeting HMGA1 in human cancers.British Journal of Cancer advance ...
Overall, we highlight that all Ptf1a-driven Cre mouse lines should be genotyped for possible germline recombination and we advise the maternal transmission of the Cre to progeny. Introduction: Identified firstly in 1981, "Causing recombination" (Cre) is isolated from P1 bacteriophage, which is ...
Here, we describe the origin of the CF neuron lineage and the involvement of Ptf1a (pancreatic transcription factor 1a) in CF neuron...doi:10.1016/j.neures.2011.07.1450Fujiyama, TomoyukiNagaoka, MaiYanagawa, YuchioMagnuson, MarkObata, Kunihiko...
51: Conversion of pancreatic progenitors to duodenal and biliary fates by Ptf1a-cre-mediated inactivation of pdx1doi:10.1016/j.jss.2006.12.062K. FuruyamaY. KawaguchiS. KodamaM. HoriguchiA. FukudaT. KuharaM. KawaguchiS. UemotoC.V. Wright...