Pterin-4a-carbinolamine dehydratase/dimerization cofactor for hepatocyte nuclear factor-1 alpha is a protein with two different functions. We have overexpressed and purified the human wild-type protein, and its Cys81Ser and Cys81Arg mutants. The Cys81Arg mutant has been proposed to be causative ...
We have isolated and characterized the cDNA and the genomic DNA encoding Drosophila melanogaster pterin 4α-carbinolamine dehydratase (PCD). The amino acid sequence deduced from the cDNA sequence was very similar to those of PCDs previously reported in other species (19–57% identity). The protein...
Pterin Carbinolamine Dehydratase/Dimerization Cofactor of HNF1doi:10.1002/0471203076.emm1128pterin carbinolamine dehydratase/dimerization cofactor of HNF1Seymour KaufmanNational Institute of Mental Health Bethesda MarylandX.D. LeiNational Institute of Mental Health Bethesda MarylandAmerican Cancer Society...
Low activity of pterin-4a-carbinolamine dehydratase (EC4.2.1.96) increases the excretion as 7-biopterin (primapterin). A methotrexate-derived compound coelutes on HPLC with oncopterin, and might be misinterpreted as a marker for cancer-specific alteration of biopterin metabolism (Hibiyaet al., ...
A 4a-carbinolamine intermediate is generated stoichiometrically during the tetrahydrobiopterin-dependent phenylalanine hydroxylation reaction catalyzed by phenylalanine hydroxylase. The dehydration of the carbinolamine is catalyzed by the enzyme, 4a-hydroxytetrahydropterin dehydratase. We have now examined the distri...
Low activity of pterin-4a-carbinolamine dehydratase increases the excretion as 7-biopterin (primapterin). A methotrexate-derived compound coelutes on HPLC with oncopterin, and might be misinterpreted as a marker for cancer-specific alteration of biopterin metabolism. 展开 出版时间: 2003/12/31 ...
in-4a-carbinolamine, which is recycled back to BH4 via R-q-BH2 by pterin-4a-carbinolamine dehydratase [3]. Deficiency in BH4 causes uncoupling of the L-arginine–NO pathway, resulting in eNOS- derived superoxide generation rather than NO formation [6]. Perox- ynitrite may then be gener...
( 1995b ) Characterization of human pterin-4a-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor1α, and of the Cys81-mutant involved in hyperphenylalaninæmia , Pteridines 6 , 123 – 125 .Köster S , Thöny B , Macheroux P , Curtius HC , Heizmann C , ...
However, molecular predictors of sorafenib efficacy have not yet been identified (2-3-4-5). Sorafe…" [more]doi:10.1007/978-3-540-29676-8_6954Markus Braun-FalcoHenry J. MankinSharon L. WengerStephan DiSean KendallJean Marie Saudubray...
(1995). Human pterin-4a- carbinolamine dehydratase/dimerization cofactor of hepato- cyte nuclearfactor-1 a. Eur. J. Biochem. 231,414-423.KOSTER, S., B. THONY, P. MACHEROUX, H.-CH. CURTIUS, C.W. HEIZMANN, W. PFLEIDERER, S. GHISLA: Human pterin-4a-carbinolamine dehydratase/...