Importantly, endoplasmic reticulum stress induced by bortezomib was enhanced by PTC596, providing an underlying mechanism of action of the combination therapy. Our results indicate that PTC596 alone and in combination with proteasome inhibition are potential novel therapeutic options to improve outcomes in...
The mechanism starting from 1 involves the displacement of DMT by CatBH, which leads to the formation of the complex [(NacNac)Zn(CatBH)]+, labeled D. The boron center's electrophilicity is increased due to the oxygen-zinc interaction of CatBH and the energy level of the CatB-based ...