PSORIASIS PATHOGENESIS: INSIGHTS FROM TRANSCRIPTOMICS AND PROTEOMICS STUDIES OF KERATINOCYTESPati, Dilip KumarMittal, PiyushVerma, ArvindJ., Devanshu PatelK., Asha.Pundir, KanikaGeorgian Medical News
Advances in the pathogenesis of psoriasis: from keratinocyte perspective Article Open access 24 January 2022 References Lebwohl, M. Psoriasis. Lancet 361, 1197–1204 (2003). This is a concise, yet comprehensive summary of the understanding of psoriasis pathophysiology and of the topical, light-...
Objective To investigate the pathogenesis of psoriasis induced by staphylococcal superantigen. Methods The proliferation responses of keratinocyte s were m... J Zhang,L Zhang,X Chen - 《Chinese Journal of Dermatology》 被引量: 7发表: 2001年 IgA deficiency and psoriasis : relevance of IgA in the...
The role of keratinocytes in psoriasis pathogenesis Keratinocytes play essential roles in both the initiation and maintenance phases of psoriasis (Fig. 1). As part of the innate immune system, keratinocytes can respond to multiple triggers. Stressed keratinocytes release self-nucleotides and antimicrobial...
Abnormal activation of inflammatory mediators from the innate and adaptive immune systems has been implicated in the pathogenesis of psoriasis. Involved cells include keratinocytes, dendritic cells, and T cells, and important inflam- matory mediators include tumor necrosis factor (TNF)-α, IL-17, IL...
The article presents information related to the pathogenesis and treatment of psoriasis. As reported, psoriasis is one of the more common chronic inflammatory diseases. According to the Central Research Institute for Ambulatory Health Care in Germany, psoriasis accounted for about one million visits to...
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on individuals, health systems, and society worldwide. With the immunological pathologies and pathogenesis of psoriasis becoming gradually revealed, the therapeutic approach
The pathogenesis of psoriasis can be explained by dysregulation of immunological cell function as well as keratinocyte proliferation/differentiation. Recently, the immunological pathomechanism has been clarified substantially. Whereas T-helper (Th)1 overactivation was thought to induce occurrence of psoriasis...
Psoriasisis an inflammatory dermatosis, considered by most authorities to be an immune-mediated disorder.5The immune pathogenesis of psoriasis is associated with a Th-1 immune response, with overproduction of the cytokines IL-2, IL-6, IL-8, interferon-γ, transforming growth factor-α (TGF-α)...
PrevalenceinChina:0.123%(1984)0.47%(2008,6cities)Morecommoninyouth&middleagedpeopleMale>FemaleCity>countrysideNorth>SouthWhiterace>yellowrace>blackrace AetiologyandPathogenesis Geneticfactors:polygenicdiseaserelatedHLA---A1,B13,B17,Cw6,etc Environmentalfactors:infection,trauma(bothmentallyandphysically),drug...