为了克服实体肿瘤的免疫抑制性微环境,Carl June 教授带领的团队让 PSMA-CAR-T 细胞表达一个TGFβRII的突变体,从而竞争性地结合 TME 中的 TGFβ。这个突变体被称为TGFβ 负显性受体(Dominant Negative Receptor, TGFβRDN),可以阻断肿瘤微环境中的 TGF-β 信号转导,进而让 CAR-T 在肿瘤微环境中能更好地发挥...
不，我们不能相信一个阴性的 PSMA PET/CT我们必须注意对列线图的解释扩大的盆腔淋巴结清扫术，以便(i)对疾病扩展的最佳评估，(ii)适应辅助治疗策略，以及(iii)可能提高生存率 原文阅读：https://www.urotoday.com/conference-highlights/eau-2024/eau-2024-prostate-cancer/151088-eau-2024-negative-staging-psma-i...
the middle image (B) shows manual segmentations (green area), and the right image (C) shows automated segmentations. The results showed false negative in prostate bed and worse performance
Rannikko 博士认为，如果补救前放疗 时PSA > 0.61 ng/mL，则补救放疗联合全身治疗(比卡鲁胺150 mg x 24个月)可改善患者无转移生存。根据兰尼科博士的说法，还有几个额外的问题 这是否意味着在这些生化复发的高危男性中，需要全身治疗来控制微转移性疾病？我们是否应该考虑 ARSI，因为它们在后续的前列腺癌发展中被...
[1] 2022 ESMO 1382P-FDG-positive/PSMA-negative PET lesion prevalence in metastatic castration-resistant prostate cancer and its correlation with lines of systemic therapy: Results from the prospective 3TMPO imaging study. [2] Cornford P, van den Bergh R C N, Briers E, et al. EAU-EANM-ESTR...
[1] 2022 ESMO 1382P-FDG-positive/PSMA-negative PET lesion prevalence in metastatic castration-resistant prostate cancer and its correlation with lines of systemic therapy: Results from the prospective 3TMPO imaging study. [2] Cornford P, van den Bergh R C N, Briers E, et al. EAU-EANM-ESTR...
[4] Su YC, Burnouf PA, Chuang KH, et al. Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy[J]. Nat Commun, 2017, 8: 15507. [5] Lau J, Jacobson O, Niu G, et al. Be...
2e5 of PSMA-CAR-293 cells transfected with anti-PSMA-scFv were stained with 100μl of 1μg/mL of Biotinylated Human PSMA, His,Avitag (Cat. No.PSA-H82Qb) and negative control protein respectively, washed and then followed by PE-SA and analyzed with FACS (Routiney tested). ...
背景与目的:前列腺特异性膜抗原(prostate-specific membrane antigen,PSMA)正电子发射计算机体层显像(positron emission tomography/computed tomography,PET/CT)和循环肿瘤DNA(circulating tumor DNA,ctDNA)的检测结果都是激素敏感性前列腺癌(h...
[2]Kloss CC, Lee J, Zhang A, et al. Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication. Mol Ther. 2018;26(7):1855-1866. doi:10.1016/j.ymthe.2018.05.003 ...