不,我们不能相信一个阴性的 PSMA PET/CT我们必须注意对列线图的解释扩大的盆腔淋巴结清扫术,以便(i)对疾病扩展的最佳评估,(ii)适应辅助治疗策略,以及(iii)可能提高生存率 原文阅读:https://www.urotoday.com/conference-highlights/eau-2024/eau-2024-prostate-cancer/151088-eau-2024-negative-staging-psma-i...
为了克服实体肿瘤的免疫抑制性微环境,Carl June 教授带领的团队让 PSMA-CAR-T 细胞表达一个TGFβRII的突变体,从而竞争性地结合 TME 中的 TGFβ。这个突变体被称为TGFβ 负显性受体(Dominant Negative Receptor, TGFβRDN),可以阻断肿瘤微环境中的 TGF-β 信号转导,进而让 CAR-T 在肿瘤微环境中能更好地发挥...
Rannikko 博士认为,如果补救前放疗 时PSA > 0.61 ng/mL,则补救放疗联合全身治疗(比卡鲁胺150 mg x 24个月)可改善患者无转移生存。根据兰尼科博士的说法,还有几个额外的问题 这是否意味着在这些生化复发的高危男性中,需要全身治疗来控制微转移性疾病?我们是否应该考虑 ARSI,因为它们在后续的前列腺癌发展中被...
the middle image (B) shows manual segmentations (green area), and the right image (C) shows automated segmentations. The results showed false negative in prostate bed and worse performance
背景与目的:前列腺特异性膜抗原(prostate-specific membrane antigen,PSMA)正电子发射计算机体层显像(positron emission tomography/computed tomography,PET/CT)和循环肿瘤DNA(circulating tumor DNA,ctDNA)的检测结果都是激素敏感性前列腺癌(h...
研究结果发表在《Nature Cancer》杂志上的一篇题为“Landscape of Prostate-Specific Membrane Antigen Heterogeneity and Regulation in AR-positive and AR-negative Metastatic Prostate Cancer”的论文中。 研究人员写道:“在15%-20%的去势抵抗性前列腺癌(CRPC)患者中,PSMA的肿瘤表达消失,但其潜在机制尚不明确。在雄...
Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is becoming standard of care for men with biochemical recurrence (BCR) of prostate cancer. The implications of a negative PSMA PET/CT scan in this population remain unclear. This study aims to ...
[4] Su YC, Burnouf PA, Chuang KH, et al. Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy[J]. Nat Commun, 2017, 8: 15507. [5] Lau J, Jacobson O, Niu G, et al. Be...
简称 99mTc-PSMA) miroSPECT/CT能清楚显示PSMA 表达阳性的前列腺肿瘤,该显像剂在体内主要 通过肾脏排泄.本课题组进一步将99mTc-PSMA 用于临床研究,以初步评价99mTc-PSMA SPECT/ CT探测前列腺癌原发灶和转移灶的价值,为前 列腺癌,特别是为复发转移,去势抵抗性前列 腺癌(castration resistant prostate cancer,CRPC) ...
Severe combined immunodeficient mice bearing PSMA-positive C4-2 prostate carcinoma xenografts were used for small-animal PET imaging. Mice with PSMA-negative DU 145 tumors served as controls. For PET studies, each animal received 20-30 microg of radiolabeled mAb corresponding to an activity of ...