临床阶段的治疗用放射药物数量超过一半集中在临床1/2期和临床1期，占比达60%，这些药物所针对的22个适应症中，排名前三的是转移性去势抵抗性前列腺癌、PSMA阳性去势抵抗性前列腺癌、前列腺癌，分别为11、2、1，占总体33%、6.1%、3.0%。而这些药物大多使用177Lu作为放射性标记的化合物。(详见附表2)4.PSMA相关...
Structure: Application: Precursor for [68Ga]DKFZ-GaPSMA-11 Presentation Packaged in amber vial or amber screw cap vials with teflon-coated stoppers under argon atmosphere. 【类别】:PSMA探针 【纯度】:99% 【说明】:可定制 【货期】:3天 【厂家】:西安齐岳生物 【图谱】:提供核磁,HPLC,LCMS,GC...
Davis, Mindy I., et al. 'Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase.' Proceedings of the National Academy of Sciences 102.17 (2005): 5981-5986. Hyväkkä A, Virtanen V, Kemppainen J, et al. More than meets the eye: scientific rationale behind ...
Product structure：二、Reaction characteristics：tert-Butyl-DCL (PSMA inhibitor)是一种常用的蛋白质组学试剂，可以用于标记和分离蛋白质。它是一种有效的生物成像剂，可以用于研究和了解细胞内蛋白质的特性和功能。作为放射显影多肽试剂，该试剂具有高度的选择性和亲和力，能够针对tumor细胞表面的特定受体进行定位和显影。
美国食品与药品监督管理局(Food and Drug Administration, FDA)在2020、2021年分别批准了 68Ga-PSMA-11、2-(3-(1-羧基-5-[(6- 18F-氟-吡啶-3-羰基)-氨基]-戊基)-脲基)戊二酸(2-(3-(1-carboxy-5-((6- 18F-fluoro-pyridine-3-carbonyl)-amino)-pentyl)-ureido)-pentanedioic acid, 18F-DCFPyL)...
Product structure: 二、Reaction characteristics: HYNIC-PSMA是一种配体,常用于正电子发射断层扫描(PET)成像技术。HYNIC是一种螯合剂,能够与PSMA(前列腺特异性膜抗原)结合,形成一种复合物。 三、Matters for use: It is sensitive to light and temperature. In order to use the reagent effectively, the materia...
EB-PSMA-617在肿瘤细胞中具有更好的内化作用和滞留效果。单次注射1.85 MBq的90Y-或3.7 MBq的177Lu-EB-PSMA-617就足以根除小鼠中PMSA阳性肿瘤。重要的是,EB修饰将血液半衰期延长至数小时,病理和血液分析均未观察到肾脏、肝脏或骨髓毒性,显示出其安全高效的...
The structure of the analysis can be applied in other environments such as web servers. The growing awareness of sustainable technologies reminds us that an ordinary incandescent light bulb, such as a 100 W bulb, initially costs about $1.50 and generates about $15 of electrical expense over its...
Results The nature of the side product was investigated by adding chelators, such as EDTA, to PSMA-11 solutions and using the combination of UHPLC-HRMS. The results led to the definition of the side product structure, as natFe-PSMA-11, from the combination of the high-affinity chelator H...
Chemical Structure Description A chemical structure of a molecule includes the arrangement of atoms and the chemical bonds that hold the atoms together. The DCL (PSMA inhibitor) (ACUPA) molecule contains a total of 42 bond(s) There are 21 non-H bond(s), 4 multiple bond(s), 11 rotatable...