Despite advancements in cancer immunotherapy, most lymphomas remain unresponsive to checkpoint inhibitors. P-selectin glycoprotein ligand-1 (PSGL-1), recently identified as a promoter of T-cell exhaustion in murine melanoma models, has emerged as a novel immune checkpoint protein and promising ...
Immune checkpoints are crucial for regulating immune responses and maintaining self-tolerance, as they play a pivotal role in preventing autoimmunity and facilitating tumor immune evasion. This review concentrates on the immune checkpoint molecules PSGL-1 and VISTA. Both molecules are highly expressed in...
2021年,AbGenomics更名为AltruBio,公司的中心也从肿瘤转向自身免疫。 2005年,全心医药即发现PSGL-1作为诱导凋亡的checkpoint可以用于治疗T细胞介导疾病。 总结 炎症性肠病在过去几年迎来诸多突破,也涌现了一批备受资本市场关注的Biotech。最大的明星无疑是TL1A靶点,Prometheus被默沙东108亿美元收购,Roivant子公司被罗氏70...
receptors are impacted by PSGL-1, this receptor could be a target for which a functional blockade could generally improve T cell responses in many clinical settings, including with tumors that are unresponsive to checkpoint inhibition and with infections for which T cell immune responses are ...
et al. PSGL-1 is an immune checkpoint regulator that promotes T Cell exhaustion. Immunity 44, 1190–1203 (2016). CAS PubMed PubMed Central Google Scholar Urzainqui, A. et al. Functional role of P-selectin glycoprotein ligand 1/P-selectin interaction in the generation of tolerogenic ...
theimmune response, PSGL-1 has emerged as an important checkpoint duringthis process. We summarize what is known regarding PSGL-1 structure andfunction and highlight how it may act as an immune checkpoint inhibitor inT cells.Coregulation of Migration and T Cell DifferentiationPSGL-1 and many ...
PSGL-1: A New Player in the Immune Checkpoint Landscape 2017, Trends in Immunology Show abstract E-selectin ligands in the human mononuclear phagocyte system: Implications for infection, inflammation, and immunotherapy 2018, Frontiers in Immunology Surface α2-3- and α2-6-sialylation of human mon...
P-selectin glycoprotein ligand-1 (PSGL-1) is an immune checkpoint regulator that is highly expressed on T cells. PSGL-1- deficient mice infected with chronic lymphocytic choriomeningitis virus (LCMV) were shown to control chronic viral infection due to increased effector function by anti-viral T ...
Abstract A051: PSGL-1-deficiency promotes pancreatic ductal adenocarcinoma tumor control and synergy with immune checkpoint blockadedoi:10.1158/1538-7445.PANCA2023-A051Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, poorly immunogenic cancer with increasing incidence rates while patient prognosis ...
Our findings show that PSGL-1 does not have a nonredundant role in the trafficking of TILs into melanoma tumors, but can act as an immune checkpoint inhibitor to limit anti-tumor T cell responses in the tumor microenvironment thereby promoting tumor growth.Roberto Tinoco...