N1-Me-pUMP·H2;N1-methyl-pseudouridine-5'-monophosphate, free acid;N1-methyl-pseudouridine-5'-monophosphate, free acid中文名: N1-methyl-pseudouridine-5'-monophosphate, free acid 中文别名: N1-甲基假尿苷单磷酸;N1-甲基-假尿苷-5'-单磷酸 CBNumber...
This was accomplished by comparing the ratio of 14C in the aglycone: ribose of the UMP and CMP with the aglycone: ribose of the pseudouridine 5′-monophosphate of the tRNA. Because of the large amounts of pseudouridine excreted into the culture medium by S. ladakanus, it was also of ...
6-Hydroxypurine Urapidil Impurity 20 ZEBULARINE Uridine 5''-Monophosphate N,N-Dibutyl-1-butanamine URAPIDIL 5-METHYL- 6-[(3-chloropropyl)amino]-1,3-dimethyluracil 2-Demethoxy-4-methoxy urapidil 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 2,4(1H,3H)-Pyrimidinedione, 1-α-L-...
We therefore here focused on theΨ-5′-monophosphate (ΨMP)C-glycosidase YeiN68,69,73,74. The enzyme catalyzes naturally the hydrolysis ofΨMP into uracil (Ura) andd-ribose 5-phosphate (Rib5P)69. The reverse YeiN reaction was promising forΨsynthesis because of two characteristics in particul...
The key precursor 5′-pseudouridine monophosphate (5′-Ψ-MP) is supplied chiefly through the action of MalD, a TruD-like pseudouridine synthase. In ... H Hong,M Samborskyy,Y Zhou,... - 《Cell Chemical Biology》 被引量: 0发表: 2019年 Transcriptome-wide analysis of pseudouridylation of...
coli MG1655 overexpressing Ψ monophosphate (ΨMP) glycosidaseand ΨMP phosphatase was obtained, which displayed the highestΨ concentration. Then, optimization of the RBS sequences, enhancementof ribose 5-phosphate supply in the cells, and overexpression of themembrane transport protein UraA were ...
Pseudouridine 5′-monophosphatePseudouridine monophosphate glycosidaseRNA modificationSemi-enzymatic synthesisModifications of RNA molecules have a significant effect on their structure and function. One of the most common modifications is the isomerization from uridine to pseudouridine. Despite its prevalence ...
Floresta, G.; Pistara, V.; Amata, E.; Dichiara, M.; Damigella, A.; Marrazzo, A.; Prezzavento, O.; Punzo, F.; Rescifina, A. Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase. Chem. ...
In this context, the poor nucleofugality of the N-protonated isoxazolidine prevents or slows down, the first mechanistic step proposed for the degradation of the pseudouridine 5'-monophosphate glycosidase, leading to the enzyme inhibition. Finally, the results of the physicochemical and ADME-Tox ...
英文别名: N1-Me-pUMP·Na2;N1-methyl-pseudouridine-5'-monophosphate, disodium salt 中文名: N1-methyl-pseudouridine-5'-monophosphate, disodium salt 中文别名: N1-甲基-假尿苷-5'-单磷酸二钠盐 CBNumber: CB46326922 分子式: 分子量: 0 MOL File: Mol file 化学...