An alignment of amino acid residues in nectin-1 of various animal species are shown, and the residues important for binding (providing 5 or more Van der Waals contacts) are denoted with arrows.doi:10.1080/22221751.2018.1563459Wong, Gary
Pseudorabies virus (PRV) is a herpes virus, also known as Aujeszky’s disease virus (ADV), which can cause a highly infectious disease pseudorabies (PR) in a variety of mammals. In the past, it has been debated whether PRV can infect humans, but more and more cases of PRV infection hav...
This potential hazard of PRV in humans has so far remained somewhat neglected despite warranting further investigation. PRV is a member of the alpha-herpesvirinae subfamily and the Varicellovirus genus15. PRV has a double-stranded genomic DNA of approximately 143 kb and contains at least 72 ...
In subject area: Medicine and Dentistry The Pseudorabies virus genome is comprised of a linear double-stranded DNA molecule of approximately 140-kb that encodes at least 70 different proteins determining virulence and pathogenesis (Kimman et al., 1992). ...
Pseudorabies, caused by pseudorabies virus (PRV) variants, has broken out among commercial PRV vaccine-immunized swine herds and resulted in major economic losses to the pig industry in China since late 2011. However, the mechanism of virulence enhanceme
BMC Genomics (2024) 25:752 https://doi.org/10.1186/s12864-024-10664-w BMC Genomics RESEARCH Open Access Analysis of the recombination and evolution of the new type mutant pseudorabies virus XJ5 in China Luyao Jiang1,2,3,4†, Jinlong Cheng1,2†, Hao Pan1,2,3,4, Fan ...
Cause: Suid herpesvirus-1 (Family Herpesviridae, subfamily Alphaherpesvirinae, genusVaricellovirus) Affected Hosts: Domestic and feral swine, cattle, horses, sheep, goats, dogs, cats, bears, raccoons, foxes, hedgehogs, opossums, deer, Florida panther, jackals, coyotes, nonhuman primates (macaques...
Recent research has unveiled the troubling capability of PRV variants to infect humans directly, inflicting serious harm to both the nervous and respiratory systems and underscoring the risk of this virus breaching species barriers (Ai et al., 2018; Wong et al., 2019; Yang et al., 2019). ...
Humans are refractory to infection. The diverse host range is also reflected in vitro, as cell cultures derived from almost any animal species support the replication of pseudorabies virus. Clinical Signs and Epidemiology Although suid herpesvirus 1 has been eradicated from domestic swine in numerous ...
we tested the hypothesis that two commonly cited factors in disease transmission, connectivity among populations and abundant resources, would increase the likelihood of exposure to both pseudorabies virus (PrV) andBrucellaspp. (bacterial agent of brucellosis) in wild pigs across the Kissimmee Valley of...