The mechanism of resistance of pseudomanas aernginosa to beta-lactam antibiotics and clini- cal significance [ J ]. J Huazhong Univ Sci Technolog Med Sci,2002,22 (4) : 339 - 342.宋建新;阮秋蓉;齐俊英;高美英;王以光.The Mechanism of Resistance of Pseudomonas Aeruginosa to β—lactam ...
aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections. The discovery and development of alternative therapeutic strategies that present novel avenues against...
Additionally, the presence of a subpopulation of cells surviving high concentrations of antibiotics, called persisters, makes it virtually impossible to eradicate a chronic infection. The mechanism underlying persistence is still unclear, partly due to the fact that it is a non-inherited phenotype. ...
Whereas all pathogenic strains of P. syringae possess the T3SS and effectors, they may or may not produce other virulence factors. Plants have evolved a defence mechanism (stomatal closure) to reduce bacterial entry through stomata by detection of pathogen-associated molecular patterns (PAMPs). To ...
Moreover, alginate might impair antibiotic penetration in biofilms being a common mechanism of adaptation to the CF51. Ciprofloxacin is extensively used for the treatment of CF patients and one of the leading mechanisms associated with resistance is the accumulation of mutations in the gyrase genes ...
Resistance to multiple drugs is usually the result of the combination of different mechanisms in a single isolate or the action of a single potent resistance mechanism. There are many challenges in the treatment of MDR P. aeruginosa and A. baumannii, especially considering the absence of new ...
CAT is a key component of the primary defense mechanism against the accumulation of hydrogen peroxide (H2O2) in cells, helping regulate its levels. The increased activity of CAT is often associated with higher levels of superoxide dismutase (SOD). When activated, SOD, in conjunction with other ...
Mechanisms were as follow: 14.5% non enzymatic mechanism, 12.5% overproduction of the constitutive cephalosporinase, 7.1% transferable betalactamase and, 6.9% combination of these mechanisms. Among the 67 transferable betalactamases: 48 (71.6%) were PSE-1, 12 (19.4%) TEM-2 and 6 (7.5%) ...
Three strains of Pseudomonas aeruginosa resistant to gentamicin obtained as representative gentamicin-resistant clinical isolates from the University of Alberta Hospital (UAH) in Edmonton, Canada were characterized to determine their mechanism of resistance. All strains showed wide aminoglycoside resistance (to...
Mechanism of eravacycline resistance in clinical Enterococcus faecalis isolates from China. Front. Microbiol. 11, 916 (2020). Article PubMed PubMed Central Google Scholar Lebeaux, D., Ghigo, J. M. & Beloin, C. Biofilm-related infections: bridging the gap between clinical management and ...