分享按钮 PSD 95(post s ynaptic density protein 95 kDa,也称为SAP 90:synapse a 90 kDa和DLG 4的关联protein)是中央突触中突触后密度的组成部分。它包含三个 PDZ 域。第一和第二PDZ结构域将NMDA受体和K +通道定位到突触,第三个与神经配素结合,神经配素是神经元细胞粘附分子,与β神经素相互作用并形成细胞...
Agarwal S, Schaefer ML, Krall C, et al. Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Sig...
Our results indicate that increased PSD-95 protects synapses from Aβ toxicity, suggesting that low levels of synaptic PSD-95 may be a molecular sign indicating synapse vulnerability to Aβ. Importantly, pharmacological inhibition of its depalmitoylation increases PSD-95 at synapses and rescues ...
Human post synaptic density protein 95; Human post-synaptic density protein 95; Post synaptic density protein 95; Postsynaptic density protein 95; PSD 95; PSD-95; PSD95; SAP 90; SAP-90; SAP90; Synapse associated protein 90; Synapse-associated protein 90; Tax interaction protein 15.靶点:详见...
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD...
Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). Thes...
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD...
PSD-95 expression also increased the number and size of dendritic spines. These results demonstrate that PSD-95 can orchestrate synaptic development and are suggestive of roles for PSD-95 in synapse stabilization and plasticity. 展开 关键词: Animals Rats Synapses Synaptic Vesicles Hippocampus Dendrites...
(synapseassociatedprotein90),是在谷氨酸能 突触的突触后密集区发现的一种脚手架蛋白,是膜 结合鸟苷酸激酶(guanylatekinase,GK)超家族的成 员之～,因分子量为90～95kD而命名.PSD-95的 功能异常与缺血性中风(ischemicstroke),老年痴呆 (Alzheimersdisease,AD),亨廷顿病(Huntingtons disease,HD)和精神分裂症(...
but they are closely related to the formation and maturation of synapse.[Key words] postsynaptic density protein 95 (PSD95);synaptophysin;neuron;synapse;cell culture突触作为神经元传递信息的主要部位,其蛋白标志物主要有突触后致密蛋白 95 (postsynaptic densityprotein 95,PSD95 )和突触小泡蛋白(synaptophysin...