Our results indicate that increased PSD-95 protects synapses from Aβ toxicity, suggesting that low levels of synaptic PSD-95 may be a molecular sign indicating synapse vulnerability to Aβ. Importantly, pharma
Agarwal S, Schaefer ML, Krall C, et al. Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Sig...
Human post synaptic density protein 95; Human post-synaptic density protein 95; Post synaptic density protein 95; Postsynaptic density protein 95; PSD 95; PSD-95; PSD95; SAP 90; SAP-90; SAP90; Synapse associated protein 90; Synapse-associated protein 90; Tax interaction protein 15.靶点:详见...
Reconstituted postsynaptic density as a molecular platform for understanding synapse formation and plasticity. Cell 174, 1172–1187 (2018). Article CAS PubMed Google Scholar Araki, Y., Zeng, M., Zhang, M. & Huganir, R. L. Rapid dispersion of SynGAP from synaptic spines triggers AMPA ...
Normal synaptic formation during neurodevelopment is critical for proper synaptic function; therefore, key components within the PSD, such as PSD-95, and SHANK help regulate synaptic growth and sustain molecular organization at the synapse. More specifically, within the prefrontal cortex, PSD-95 plays...
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell 2012; 151: 1581–1594. Article CAS PubMed PubMed Central Google Scholar Rashid AJ, Cole CJ, Josselyn SA . Emerging roles for MEF2 transcription factors in memory. Genes Brain...
(synapseassociatedprotein90),是在谷氨酸能 突触的突触后密集区发现的一种脚手架蛋白,是膜 结合鸟苷酸激酶(guanylatekinase,GK)超家族的成 员之～,因分子量为90～95kD而命名.PSD-95的 功能异常与缺血性中风(ischemicstroke),老年痴呆 (Alzheimersdisease,AD),亨廷顿病(Huntingtons disease,HD)和精神分裂症(...
FLJ98574; Human post synaptic density protein 95; Human post-synaptic density protein 95; Post synaptic density protein 95; Postsynaptic density protein 95; PSD 95; PSD-95; PSD95; SAP 90; SAP-90; SAP90; Synapse associated protein 90; Synapse-associated protein 90; Tax interaction protein 15...
Cell junction > synapse. Found in postsynaptic density of neuronal cells. Tissue Specificity : Expressed in brain. Similarity : Belongs to the SAPAP family. Database links : UniProtKB/Swiss-Prot: O14490.1 Anti-VEGF-D/FIGF/FITC 荧光素标记兔抗人、大、小鼠内皮生长因子D型VEGFD抗体IgGMulti-class...
Disks large homolog 4; Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90; PSD95; DLG4 氨基酸序列 MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVM...