造模前7 d开始灌胃,手术后5 d继续灌胃,共60 d.Morris水迷宫实验,Y迷宫实验及旷场实验检测小鼠学习记忆和空间探索能力;蛋白质印迹法检测小鼠海马LSD1,PSD95,突触素(SYN),白细胞介素-1β(IL-1β),肿瘤坏死因子-α(TNF-α)蛋白表达及组蛋白H3第9位赖氨酸二甲基化(H3K9me2)修...
Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domainsdoi:10.1016/S0092-8674(00)81053-3Neuronal nitric oxide synthase (nNOS) is concentrated at synaptic junctions in brain and motor endplates in skeletal muscle. Here, we show...
Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brain. Synapse 65 763–770 10.1002/syn.20900 [ Cross Ref ]Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95,NR1,and synaptopodin in the mouse brain. Cohen JW...
Thus, chapsyn-110 and PSD-95 may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signalling proteins.doi:10.1016/S0896-6273(00)80284-6Eunjoon KimK O ChoAdam Rothschild...