Similarly, slices prepared from transgenic mice lacking the NCAM gene exhibited a decaying LTP. No inhibition of N-methyl-D-aspartic acid receptor–dependent synaptic responses was detected. Washout of the enzyme resulted in reexpression of PSA immunoreactivity which correlated with a complete recovery...
Similarly, slices prepared from transgenic mice lacking the NCAM gene exhibited a decaying LTP. No inhibition of N-methyl- D -aspartic acid receptor–dependent synaptic responses was detected. Washout of the enzyme resulted in reexpression of PSA immunoreactivity which correlated with a complete ...
Molecular profiling, global gene analysis, and multilineage differentiation of PSA-NCAM− cells confirm that they are multipotent neural crest stem cells (NCSCs) that could differentiate into both ectodermal and mesodermal lineages. Transplantation of PSA-NCAM− cells in a gradient manner mixed with...
Entrez Gene ID: (Human) 4684, (Mouse) 17967, (Rat) 24586 功能 virus receptor activity Ras guanyl-nucleotide exchange factor activity protein binding heparin binding phosphatase binding LRR domain binding identical protein binding fibroblast growth factor receptor binding cytoskeletal protein binding ...
Genetic and pharmacological aspect of histamine H3 receptor hetero- geneity. Life Sci 73: 3043–3072. Hancock AA, Blitner RS, Krueger KM, Otte S, Nikkel AL, Fey TA et al (2006). Distinctions and contradistinctions between antiobesity histamine H3 receptor (H3R) antagonists compared to ...
In a parallel vein, interference with hippocampal NCAM functioning by conditional ablation of the NCAM gene in adult mutant mice (NCAMff+) yielded mimicry of the deleterious effect of stress exposure on both long-term potentiation (LTP) and long-term depression in the CA1, as well as on ...
An Association Study between the NCAM Gene and Schizophrenia; NCAM基因与精神分裂症的连锁不平衡研究 9. The Expression of RET Protein and NCAM in Hirschsprung s Disease; RET蛋白、NCAM在先天性巨结肠症中表达的意义 10. The Role of NCAM-1, MMP-9 and TIMP-1 in Human Brain Gliomas Invasion; ...
Yabe T, Rosenthal ES, Krzan M, Schwartz JP: PSA-NCAM distinguishes reactive astrocytes in 6-OHDA-lesioned substantia nigra from those in the striatal terminal fields - Nomura () Citation Context ...ghts of 120, 140, and 180 kDa are derived from the single gene. NCAM-120 is the ...
Gene expression profiles and exocytosis machinery were also investigated. In a second part, βhigh and βlow-cell distribution and functionality were investigated in animal models with decreased or increased β-cell function: the Zucker Diabetic Fatty rat and the 48 h glucose-infused rat. Results:...
Moreover, PCE reduced gene and protein expression of neural cell adhesion molecule (NCAM) and polysialylated-NCAM (PSA-NCAM), which are critical for GluN2A and GluN2B signaling balance. Administration of exogenous PSA abrogated the LTP deficits observed in PCE animals, suggesting ...