WHAT IS THE SENSITIVITY AND SPECIFICITY OF THE PROSTATE SPECIFIC ANTIGEN (PSA) TEST FOR PROSTATE CANCER? SCREENING STUDIES ARE SUBJECT TO VERIFICATION BIAS AND STATISTICAL CORRECTIONS ARE INADEQUATE IN THIS SETTINGpriapismsubarachnoid hemorrhagetreatment...
have reported that a threshold value <10% implies a positive predictive value (PPV) of 55% (obtained by maximizing the specificity at 80%) and a ratio between PCa of any grader missed and unnecessary biopsies avoided of ∼1:3.3 in the range of tPSA 4.0–10.0 μg/ L (no data ...
Age-specific-PSA-values had a comparable specificity (38.4 %), but sensitivity was only 80.8 %. The PSA-density (cut-off level 0.15) for patients with PSA-values between 2.0 and 10.0 ng/ml had a sensitivity of just 20%, but specificity was very high (81.8 %). The combination of DRE...
血清PSA密度变化对前列腺癌的诊断价值
Diagnostic performance was evaluated by using the area under the curve (AUC) of receiver operating characteristic (ROC) curve, sensitivity and specificity, and the differences between AUC values were compared by the DeLong test. ResultsAge, total prostate specific antigen (tPSA), prostate volume ...
The multivariate logistic regression analysis was also performed through SPSS to select the independent risk factors for prostate cancer (PCa) and clinically significant cancer (csPCa). The receiver operating characteristic curves were also constructed to analyze the sensitivity and specificity of PI-RADS...
Improvement of Sensitivity and Specificity of PSA Screening: The above mentioned facts explain the low sensitivity and specificity of PSA screening. An improvement can be achieved by using age-specific reference ranges, free PSA concentration (fPSA), PSA-density, PSA-velocity and observing a longer ...
When the cut-off value was 0.584,the sensitivity was 71.4% and the specificity was 84.7%,both higher than those of the individual indicator alone(both P < 0.05). Conclusions IL-6 and IL-10 levels have certain clinical value in the diagnosis of prostate cancer. Age,tPSA and IL-6 are ...
cer,andthetestresultswereanalyzedbyROCcurves.ResultsTheoptimalthresholdvaluewas5.35ugL,whichhada sensitivityof70.6%andaspecificityof81.8%.TheareaundertheROCcurve(ACU ROC )was0.72.Theresultsdemonstrat edreliabilityandvalidityinclinicaldiagnosticwork-up.ConclusionsROCcurvesarevalidindetectionofPSAandde terminationof...
Although serum PSA has been used as a screening test for prostate cancer for over 20 years, the practice is controversial. As a screening test for prostate cancer, PSA lacks sensitivity and specificity for early disease. Furthermore, screening may lead to unnecessary biopsies, overdetection, and...