【25】Such statistical modeling studies have important limitations and rely on unverified assumptions that can render their findings questionable (or more suitable for further study than to serve as a basis for screening guid...
Reports on the issuance by the National Comprehensive Cancer Network of a new prostate cancer screening guidelines in the U.S. Life expectancy of men aged 50 years; Importance of prostate-specific antigen (PSA) as a diagnostic tool for prostate cancer; Criticism concerning PSA as a screening ...
New guidelines on prostate cancer screening, issued today by the American Urological Association (AUA), are supportive of routine use of the prostate-specific antigen (PSA) test in healthy men, but only for a specified age group, and only after discussion between a man and his physician. Speci...
[30] Roobol MJ, Roobol DW, Schröder FH. Is additional testing necessary in men with prostate-specific antigen levels of 1.0 μg/L or less in a population-based screening setting? (ERSPC, section Rotterdam). Urology...
Historical prostate-specific antigen (PSA)-based screening studies reduced prostate cancer-related deaths but also led to overdiagnosis/overtreatment. Since then, opportunistic PSA testing has increased, and late-stage diagnoses and prostate-cancer relat
The PSA screening blood test measures the levels of PSA circulating in the blood. Both normal prostate cells and cancer cells make PSA. While prostate cancer cells tend to produce less PSA than normal cells, they allow PSA to more easily pass through the cell wall and eventually wind up in...
assays 143 inter-method bias of tPSA and fPSA measurements might be tolerated or the method-dependency of tPSA and fPSA results may contribute to an unfavorable risk-benefit ratio of the PSA based-screening strategy as it has been endorsed by recent Clinical Practice Guidelines (CPG) [2, 5]...
PSA Screening Among Elderly Men With Limited Life Expectancies Most guidelines do not recommend prostate-specific antigen (PSA) screening in elderly men who have limited life expectancies because the known harms of scr... LC Walter,D Bertenthal,K Lindquist,... - 《Jama the Journal of the ...
it has been observed that approximately one in every seven men diagnosed with prostate cancer will maintain normal PSA levels3. These findings highlight the limitations of relying solely on PSA screening for prostate cancer diagnosis. As a result, some countries have started to limit their recommend...
The total PSA testing has been frequently criticized for its effectiveness in the early detection of prostate cancer. These widely resumed in and out of the medical community have led to a decrease in prescriptions. Recommendations against the use of PSA for screening have been issued in France ...