Study: PSA level changes important; Prostate cancer fatality rate seems linked to how rapidly test numbers fluctuateASSOCIATED PRESS
Aim: The objective of this study is to assess NNT, numbers needed to treat to harm and corresponding confidence intervals for radical prostatectomy (RP) in patients with prostate cancer defined as a PSAV ≤2 ng/ml/year. Methods: NNT following RP were estimated in risk groups defined by PS...
Screening for prostate cancer continues to generate controversy because of concerns about over-diagnosis and unnecessary treatment. We describe the rationale, design and recruitment of the Cluster randomised triAl of PSA testing for Prostate cancer (CAP)
PSA levels present great variability among patients; this is explained by different PSA expression by prostate cancer cells and tumour cell heterogeneity [19]. The interpretation of PSA values is further complicated by the fact that some patients who demonstrate increased values after initial treatment...
7 As PSA is synthesized in malignant cells, it can also be synthesized in benign conditions such as aging, benign prostatic hyperplasia (BPH), prostatitis and prostate infarction, where the structure of the prostate tissue is disrupted. For this reason, an increase in serum PSA levels can be ...