On the other hand, for patients undergoing hormone therapy or active surveillance, the target PSA level may be set at a level that indicates stable disease or slow progression. It is important to note that PSA levels alone cannot definitively diagnose or monitor prostate cancer. Other factors, ...
Prostate-Specific AntigenRemission InductionFollow-Up StudiesMaleObjectives. The prostrate-specific antigen nadir that indicates potential cure by radiotherapy has never been established. We determined this nadir level and used it to define precisely disease freedom after radiotherapy.;Methods. Combination ...
Thus, if the initial PSA reading is about 10 ng/mL and it rises rapidly year on year, this can point to early-stage prostate cancer. Most research indicates that an increase of 0.75 ng/mL a year is an early indicator of prostate cancer if a man has a total PSA result between 4.0 ...
Research indicates that 1 out of 4 men with elevated PSA levels will actually have prostate cancer. Additionally, it has been observed that approximately one in every seven men diagnosed with prostate cancer will maintain normal PSA levels3. These findings highlight the limitations of relying solely...
As seen in the table a small number of men with a low PSA level may still have prostate cancer although this is usually likely to be at a very early stage. A normal result for a man over 55 can be reassuring as it indicates you are unlikely to have an aggressive cancer at the time...
The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical...
At the cellular level, PCa contains differentiated cancer cells expressing high levels of PSA (i.e., PSA+), as well as PCa cells that express little or no PSA (i.e., PSA−/lo). The PSA−/lo cells appear to be rare in early-stage tumors but become more abundant in high-grade ...
Despite the potential of using biochemical recurrence as a potential marker to predict overall survival in patients with prostate cancer, the results of the study indicates that it should not be the main focus or primary measure in futureclinical trialsfor localized prostate cancer. Instead, metastasi...
to its usual carrier molecules, the protease inhibitors; free PSA is used to distinguish prostate CA from BPH, etc; free PSA levels are measured in Pts with a total PSA level between 4 and 10 ng/mL and nonsuspicious digital rectal examinations; ↑ free PSA indicates a ↓ risk of CA....
Increased expression of CELSR3 indicates a poor prognostic factor for Prostate Cancer CELSR3-related hub genes (CENPE, CENPA, CDC20, NUF2, ESPL1, PLK1) were selected and the functions of these hub genes showed that the function of ... X Chen,Q Ma,Y Liu,... - 《Journal of Cancer》...