Percentage of fPSA contributes to modest diagnostic enhancements above and beyond tPSA alone among men in the “diagnostic gray zone”54. High %fPSA was also shown to be associated with worse survival outcome in patients with biochemical recurrence, indicating that fPSA may have role in progression...
Accordingly, recent studies are developing PSA-based risk models as an aid in the personalized management of the diagnostic workup of PCa, to improve the risk-benefit ratio of the patient, reminding that the ratio of one cancer detected of any grade for every three performed biopsies is ...
routine screening in blood for the prostate-specific antigen (PSA), a 28.4 kD serine protease secreted by the epithelial lining of the periurethral glands and the prostatic epithelium, has increased the diagnostic efficiency of prostate cancer from 8% to 18% in less than three decades [3]. Ho...
Performance of the prostate cancer antigen 3 (PCA3) gene and prostate-specific antigen in prescreened men: Exploring the value of PCA3 for a first-line diagnostic test. Eur. Urol. 2010, 58, 475–481. [CrossRef] [PubMed] 48. Tomlins, S.A.; Rhodes, D.R.; Perner, S.; Dhanasekaran...