Because PSA levels test scores can be influenced by a large number of factors unrelated to prostate cancer, a high test score may cause you to submit to a possibly unnecessary or life threatening biopsy. And: You now have a better option! Be Well... ~ William...
Results. Response rates were 59% at invitation, 77% after PSA blood test, 54% after PSA result and 69% after DRE. The men recruited at each stage... Vasarainen,Hanna,Malmi,... - 《Acta Oncologica》 被引量: 12发表: 2013年 加载更多来源...
The New England Journal of Medicine states:"(the) PSA level test has been found to miss 82 percent of tumors in men under 60, and 65 percent of cancers in older men". This data is erroneously causing some scientists to recommend that men with even lower resulting scores have biopsies! Th...
is changing, with advances in imaging (eg, multiparametric magnetic resonance imaging) being introduced with prostate biopsy to improve the identification and targeting of clinically important cancer,33 and blood-based biomarkers to enhance the specificity of the serum PSA test, including genetic testing...
Since the late 1980s, the diagnosis and follow-up of prostate cancer (PCa) has relied on the use of prostate-specific antigen (PSA), a blood laboratory measurement that was shown to be associated with pathological diagnosis of cancer and... M Lazzeri,G Guazzoni,F Montorsi - Prostate Cancer...
2011 ASCO Annual Meeting Results from a 30-year study of Swedish men showed that close monitoring of men with the highest 10% of PSA scores could prevent nearly half of all prostate cancer deaths.
Graph on the right shows difference in PSA expression scores between [T] and [C] allele (CC: n = 2, CT: n = 10, TT: n = 10) for the immunohistochemical samples. The box plot centre line represents median, the boundaries represent interquartile range (IQR) and min and...
. Another approach, derived from these scores and estimated in large populations, is the risk calculators (RCs) prediction models, developed to assess patient’s individual PCa risk, which show a moderate to well discriminatory ability to predict PCa25. There are other prognostic scores based on ...
PolyPhen and SIFT scores predict the effect of an amino acid substitution on structure and function of a protein, using sequence homology, proximity of the substitution to predicted functional domains or structural features, and physicochemical similarity between alternate amino acids. Data availability ...
We also calculated polygenic risk scores (PRSs) to estimate the contribution of variants that associate with BPH/LUTS or prostate cancer, respectively, to variation in PSA levels. We used effect estimates from the GWAS of BPH/LUTS and prostate cancer in the UK samples to generate PRSs to corre...